September 19, 2020

The Niche

Knoepfler lab stem cell blog

Month: August 2010

2 min read

The Obama administration has announced it will “quickly” appeal the ES cell decision, but I’m not hearing anything about a stay on the judge’s order in the meantime or anything like that. It’s quite the opposite. The NIH, in the form of Director Francis Collins, has finally spoken about the federal judge’s ruling that apparently banned federal funding for human ES cell research. Dr. Collins’ statement brings some clarity, but would seem to indicate the most grim interpretation of yesterday’s ruling are turning out to …Read More

3 min read

UPDATE: A second recent study, this one in Nature Genetics has found a novel genetic link between the immune system and Parkinson’s Disease. The authors were screening for genomic variants unique to Parkinson’s patients, finding known ones but also a novel linkage. The link was with the HLA region, known to play a key role in immunity. This study supports the hypothesis that is gathering steam in the field that there is an immune component to PD, specifically an inflammatory aspect to the disease. …Read More

4 min read

UPDATE: I have added more discussion at the bottom about therapeutics and how regenerative medicine might work for Alzheimer’s Disease. Alzheimer’s Disease (AD) is the most common cause of dementia throughout the world, affecting 10s of millions of people. The cost to society is staggering and on a personal level for those of us who have had relatives with the disease, the personal fallout is just as enormous.  The last week has seen some very exciting news about research into AD giving more reason …Read More

2 min read

This is the first post in a series focusing on stem cell advances related to specific diseases. Today we discuss Huntington’s Disease and a paper that came out yesterday in the journal Neuron that provides some significant insight into the mechanisms behind the disease. It is entitled: Huntingtin Is Required for Mitotic Spindle Orientation and Mammalian Neurogenesis Huntington’s Disease (HD) is a genetic disorder characterized by progressive neurological problems caused by neurodegeneration. The cause of HD was discovered to be mutations in a gene …Read More