January 18, 2021

The Niche

Trusted stem cell blog & resources

Month: October 2010

3 min read

If IPS cells are not ready for prime time, it is probably due to these three critical challenges for these amazing cells. TUMORIGENICITY Those of us who work with IPS cells are very excited about their potential for use in regenerative medicine therapies. One serious hurdle we have talked about in the past is tumorigenicity. COST Another hurdle that is far less discussed, but is equally critical, is the potential cost of IPS cell based therapies. The therapeutic advantage of IPS cells over ESC …Read More

3 min read

Cancer is a class of diseases that are intimately linked to stem cells. In fact, I would go so far as to call some types of cancer cells and stem cells, cousins. This concept, of a tight relationship between stem and cancer cells, is under intense investigation but at the same time it is something that many stem cell scientists would rather not think about. It is simply reality. A wide variety of cancers exhibit gene expression profiles that share modules with highly pluripotent …Read More

3 min read

It has been an eventful year so far for the stem cell field. Where do we go from here ? What are the key questions that face the field? Below are my top 10 questions for the field, NOT listed in any particular order, and some predictions. Update: you can see the predictions for the years 2018, 2019, and 2020. 1)   How will Geron’s Phase I Clinical Trial go? Will GRNOPC1 be safe? When will we know? Barring any major catastrophic events, it may …Read More

3 min read

One question I am frequently asked by readers and colleagues is “what other stem cell blogs or bloggers can you recommend that are written by a stem cell scientist and updated on a regular basis?” The simple but surprising answer: there are none. It’s lonely out here in cyberspace! (2020 update: The good news today is that there are many stem cell blogs out there in total, but unfortunately some are by stem cells clinics or their advocates and not really active ones by …Read More

2 min read

CIRM Board Member, Jeff Sheehy, has a wonderful piece in Nature Medicine on why patient advocates play a critical role in decision making on research priorities (hat tip to Amy Adams who first blogged on Sheehy’s piece). Patient advocates bring a unique and valuable perspective to the table. Their role in guiding CIRM research funding decisions has had a clear impact. Scientists must be advocates too. Traditionally, scientists have not been comfortable acting as advocates, but in the current environment scientists must take action …Read More

2 min read

Dr. James Sherley, the scientist behind the lawsuit against federally-funded ES cell research, has penned an opinion piece in The Daily Caller today calling on NIH to, in his words, ‘do the right thing.’ However, what Sherley is really asking is for the NIH, other stem cell scientists, and all Americans to think like he does. In fact, U.S. News and World Report just came out with a poll indicating that 72% of Americans support embryonic stem cell research using lines that remain from …Read More

3 min read

2020 update: This post from almost 10 years ago on the HIV pandemic and particularly the first paragraph ring differently in the context of the COVID-19 novel coronavirus pandemic. Over the last several years, there has been great concern about a possible flu pandemic around the world, but meanwhile the great pandemic of modern history, HIV/AIDS, continues. There are now more than 33 million HIV infected individuals. More than 2 million people have died from HIV infection in 2008 alone, approximately 1 out of …Read More