Year: 2010

Tumorigenicity and Pluripotency teased apart? Not yet for Myc

February 1, 2021 / By
Fig.-5-Nakagawa-et-al.-Myc-in-cancer-and-IPScs

A paper just came out in PNAS entitled “Promotion of direct reprogramming by transformation-deficient Myc“. The main thrust of this paper is that the tumorigenic and pluripotency-related functions of Myc could be separated. It focused primarily on the lesser studied LMyc. The topic of the intertwined good (pluripotency) and bad (tumorigenicity) functions of Myc, addressed …

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Striking iPS cell research publishing trends: what do they mean?

February 1, 2021 / By
Dopamine-neurons-derived-from-a-Parkinsons-disease-patients-iPSCs-Tyrosine-hydroxylase-1

Update in 2020: Wow, a lot has changed since this post almost 10 years ago, but Cell Stem Cell remains the main publisher of IPS cell articles still. The young iPSC field has published a truly massive number of papers in just 4 years. Searching ISI Web of Knowledge for papers with titles reflecting iPSC …

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iPS cells coming into focus: not quite so similar to ESC after all

February 1, 2021 / By
FaviconIPSCELL

Update in 2020: It seems now after all these years that the consensus in the now more mature field is that IPSCs and ESCs are nearly identical in most cases, and both have some of the same translational challenges such as teratoma-forming activity. It’s interesting to read this post from nearly 10 years ago and …

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