August 7, 2020

The Niche

Knoepfler lab stem cell blog

Month: October 2012

2 min read

The Houston Chronicle has posted the response letter from Celltex to the FDA in regard to the FDA Warning Letter issued to Celltex. The Chronicle also has a piece up on the warning letter that is a great read here. My thoughts on the possible paths for Celltex moving forward can be found here. The Celltex letter sheds further light on possible futures for the company. While partially redacted (actually the redactions are seemingly minimal), it is fascinating reading although rather dense at times …Read More

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Hisashi Moriguchi. He is arguably at the center of one of the biggest science scandals of 2012. This is the guy who lied about doing iPS cell transplants into human patients. He also lied about being affiliated with Harvard & its primary teaching hospital, Massachusetts General Hospital (MGH), for many years after he left there. He claimed in two 2012 papers to have Harvard IRB approval that he did not have. Some folks have asked me how stem cell scientists didn’t realize what this guy …Read More

1 min read

Hisashi Moriguchi, the fellow who made up the story of having transplanted iPS cells into human patients and then later admitted that he had lied, has been fired by the University of Tokyo according to a statement (here in Japanese) from the university. An admittedly fairly weak translation to English by Google is the following: Press release list Publication of disciplinary action October 19, Heisei 24 Adjunct Researcher, University Hospital for Hisashi Moriguchi, dated October 19, the University of Tokyo, we conducted a disciplinary …Read More

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A team from the Salk Institute in La Jolla led by Inder Verma has reported in a paper in Science some hugely important findings that I believe make their paper in the top 10 as a candidate for paper of the year. The paper, entitled “Dedifferentiation of Neurons and Astrocytes by Oncogenes Can Induce Gliomas in Mice” makes striking findings. The authors show that mature neurons and astrocytes (incredibly specialized, “terminally differentiated” cells) can be dedifferentiated. This is groundbreaking because these types of cells, …Read More