July 13, 2020

The Niche

Knoepfler lab stem cell blog

Month: November 2012

3 min read

There’s a new paper out this week in Cell from the Zaret lab that is very exciting. In this manuscript, Facilitators and Impediments of the Pluripotency Reprogramming Factors’ Initial Engagement with the Genome, Zaret’s team explores how Myc and Oct4, Sox2, and Klf4 (OSK) behave at the genomic level during cellular reprogramming. What are the most exciting and interesting points of this paper? The team finds that Myc and OSK behave in some unexpected ways. For example, Myc greatly enhances the binding of OSK to …Read More

3 min read

Supposedly there is a type of normal adult stem cell that intrinsically possesses many of the same properties as embryonic stem cells (ESCs). No reprogramming needed. No blastocysts needed. These reportedly amazing cells, called Very Small Embryonic-Like Stem Cells (VSELs), can in theory be isolated from umbilical cord blood (UCB) or even bone marrow. Yet they are pluripotent like ESCs. They seem to be present in mice and possibly in humans. Wow, you say, VSELs seem like the best thing since sliced bread? No …Read More

1 min read

I did a poll of what people think Nasa’s big announcement that they said is coming about a history-making discovery of the Mars Rover. The results are above. The top two answers, adding up to nearly 60% of responses, represent very high expectations as both would suggest life has existed on Mars. If you take them together with actual life on Mars and DNA (could only come from life) add up to 72%.

1 min read

The Vegas trial of Dr. Ralph Conti, accused of dangerous stem cell fraud, is going on and reportedly some of the testimony is astonishing in terms of the attitudes of point-of-care, for profit stem cell clinic disregard for their patients. The doctor is quoted that in terms of the stem cell treatments of human patients that he and his partner Alfred Sapse were “making it up” as they went along. Holy cow, that is a scary statement. Just as bad, Conti also said sometimes …Read More