August 8, 2020

The Niche

Knoepfler lab stem cell blog

Month: March 2014

4 min read

What next for STAP? Is retraction of the two papers on the near horizon? It has been two months now since Nature published the two papers on STAP cells and STAP stem cells. There has been a storm of controversy surrounding these papers and the claims they made to easily produce the most powerful of stem cells with simple stresses such as a exposure to a weak acid bath. To my knowledge no one independent of the STAP groups themselves has gotten this technology …Read More

6 min read

Advanced Cell Technology (ACT; $ACTC) has a new paper out on using human embryonic stem cells (hESC) to make MSCs with potentially powerful therapeutic potential. The paper, entitled Mesenchymal stem cell population derived from human pluripotent stem cells displays potent immunomodulatory and therapeutic properties, was published in the journal Stem Cells and Development. What’s the scoop on this paper and this area of adult stem cell preclinical/clinical research? It’s an interesting, notable paper. At the same time there are some areas in the paper that could have been …Read More

3 min read

I don’t really hear from almost anyone who fully believes in the STAP cell thing anymore. The most common thing I do hear is from people assuming STAP is largely or entirely wrong and asking, “what really happened?” There’s still a chance that STAP is real, but if I were in Vegas or at the race track I’d put the odds in the single digits at this point. Betting on STAP to be entirely true today would be akin to wagering on a 100-1 …Read More

2 min read

Dr. Ken Lee’s lab has done some very important validation attempts on STAP cells and has posted them on ResearchGate. To my knowledge, his lab’s STAP experiments are the ones in the public domain that most closely matched the methods of the Nature STAP papers. Dr. Lee submitted the work to Nature Brief Communications Arising on STAP cells, but sadly the manuscript was rejected by Nature. Dr. Lee sent me a copy of the rejection letter from Nature and gave me permission to post …Read More