September 30, 2020

The Niche

Knoepfler lab stem cell blog

Month: June 2014

2 min read

It was great being a postdoc in Bob Eisenman’s Lab at the Hutch in Seattle. I loved it.  Bob is a great mentor (see more on my experience there here) and the scientific interactions in the lab were wonderful. It’s been fun and interesting to follow the work of my fellow former Eisenman lab members over the years. For example, another former postdoc from the Eisenman lab, Shaun Cowley, has a lab that is doing some exciting research on the role of histone deacetylase (HDACs) in …Read More

2 min read

As the STAP cell fiasco has evolved, there has been discussion of various possible resolutions or even penalties for those involved, both institutions like RIKEN and individuals. One of the most extreme and I believe way out of proportion potential outcomes suggested has been the dismantling of RIKEN’s entire Center for Developmental Biology (CDB) in Kobe. An outside reform panel has reportedly suggested to RIKEN President Ryoji Noyori that CDB be dissolved. While it is true that Obokata was working at CDB and a few …Read More

1 min read

I’ve conduct two polls after the annual ISSCR 2014 meeting in Vancouver. Both reflect a moderate level of enthusiasm. The results are above. In the first poll, asking for a general level of enthusiasm about the meeting (let), the top answer was the middle of the road “so-so”, but this was followed by the two possible answers reflecting positive feelings about it. In the second poll at right, I ask respondents how they felt about ISSCR 2014 versus ISSCR 2013. Again, the responses were …Read More

3 min read

A new patent has been awarded to James Sherley for a very unusual method claimed for making induced pluripotent stem (iPS) cells. The patent, No. 8,759,098, claims that a single non-genetic chemical agent, xanthine, can by itself reprogram adult stem cells (ASC) into iPS cells (aka iPSCs; see image they released at left). Surprising patent, huh? Another notable element to this patent story is the identity of the patentee: Dr. James L. Sherley. Sherley fought a court battle (Sherley v Sebelius) with the Obama administration seeking to ban all …Read More