October 30, 2020

The Niche

Knoepfler lab stem cell blog

Month: February 2015

4 min read

Dr. Christopher Fasano, principal investigator at the Neural Stem Cell Institute and creator and host of THE Stem Cell Podcast founded a unique stem cell meeting in 2013. In this short interview I find out about The Next-Gen Stem Cell Conference (to be held this year on May 6-7) and how it differs from the others. What is the Next-Gen Stem Cell Conference? The Next-Gen Stem Cell Conference is a meeting where young stem cell scientist get together in a causal setting to exchange …Read More

2 min read

A cool new paper is out in Stem Cell Reports describing long-term tumorigenicity of human induced pluripotent stem cells (IPSC or IPS cells). See graphical abstract. The potential tumorigenicity of IPSC is a major concern when teams around the world are translating IPSC technology to the bedside. Past studies including one from my own lab have shown that there are some parallels between cellular reprogramming to make IPSC and tumorigenicity. MYC has often been viewed as the likely culprit but this paper expands the potentially …Read More

2 min read

The still mysterious BioGatekeeper had challenged Yamanaka’s IPS cell patent claiming that it was obvious. The potential implications were huge given the commercial interest in translating IPS cell technology. For background see here, here, and here. There’s pretty much zero information on BioGatekeeper otherwise. Despite the potential seriousness of this patent challenge, just a few days ago the Patent Trial and Appeal Board (PTAB) denied the challenge so for all intents and purposes BioGatekeeper’s effort is dead. A big hat tip to reader Shinsakan. You …Read More

6 min read

On Thursday here at UC Davis School of Medicine we held our second annual Stem Cell Ethics Symposium. The symposium was organized by Drs. Mark Yarborough and Nanette Joyce as well as me. In this post I report on key take homes from the meeting and summarize the specific talks. As far as I know, this is one of the few events in the world where there is such a wide diversity of stakeholders present both as speakers and in the audience to specifically discuss stem cell ethics for a full …Read More