July 10, 2020

The Niche

Knoepfler lab stem cell blog

Month: February 2018

3 min read

There’s much more to CRISPR-Cas9 than just gene editing and a new paper from the lab of Rudy Jaenisch in Cell highlights that in an exciting way. It reports epigenetic reversal of a Fragile X Syndrome phenotype in induced pluripotent stem cell (IPSC) neurons. Fragile X Syndrome is a neurological disorder in boys resulting from CGG repeat expansions in the regulatory region of the FMR1 gene and associated epigenetic alterations including DNA methylation that tend to shut off gene expression. The new paper, Liu, et al., …Read More

4 min read

What happens if we mix stem cells with populism? From a populist view of stem cells, everyday patients should be able to do nearly anything they want with stem cells without any governmental interference or excessive expense. Even stem cells not proven to be safe or effective. This can sound like an appealing idea to patients looking for hope and also to some companies looking for profits. Stem cell populism poses serious questions and risks too. What exactly is “populism”? The Internet defines it …Read More

2 min read

One of my hobbies is gardening, which helps keeps one’s sanity amongst all the grant writing, etc. However, I have a tough time leaving the science behind when I go out into the garden so sometimes I give in and go all science nerd in the garden. I’ve been doing a series on my blog of occasional posts that I call The Scientist in the Garden. Recently when I went out in the garden with my iPhone equipped with a zoom lens (photography being …Read More

4 min read

I’ve been blogging about stem cells now for about 8 years and the recent level of hype about and fluffy media coverage of Celularity, the biotech spun out of Celgene, ranks right up here with the most extreme past cases I’ve seen. What is Celularity and who is its leadership? It’s a new biotech focused on placental stem cells with some familiar, well-known leaders including Bob Hariri and Peter Diamandis, and famous tech names on their board including John Scully and Bill Maris, along …Read More