January 25, 2021

The Niche

Trusted stem cell blog & resources

Month: July 2020

2 min read

I’m doing an experiment today to see if people enjoy a mid-week splash of a few Wednesday recommended science reads and the first one collides with art. You can see Sunday’s recommended weekly reads here too. Also, be sure to visit our Facebook page if you have a moment and please like our page if you like what you see. An Artist Who Reanimates Extinct Species This is extremely cool work by artist Marguerite Humeau. It in turn reminds me of de-extinction (at least virtual …Read More

6 min read

I wrote last week about the Nebraska and Iowa state Attorney Generals filing lawsuits against stem cell clinic firms and three individuals also named as defendants. Although I went into detail about the individuals including leader Travis Autor and the firms, I didn’t yet go into much depth on the state lawsuits themselves in that post. For more on this critical part of the story I needed some expert input so I turned to attorney Beth Roxland for a Q&A. She has unique expertise …Read More

5 min read

Ready for the latest recommended weekly reads in the world of stem cells and the regenerative medicine space including a bunch of important new FDA posts & changes? This post has quite a lot on the FDA since it had a very big week with several new items of major importance to the cellular and regenerative medicine arena. I’ve linked to each announcement below with the agency’s title of the announcements. Underneath I provide some analysis and ask questions. I’ve also included some other stem …Read More

8 min read

Some readers suggested earlier this year that I look into a clinic firm called ‘Stem Cell Centers’ with its owner Travis Autor. I didn’t have time to do much since I’ve been very busy in the lab before the state Attorney Generals of Iowa and Nebraska sued them based on a number of allegations including in the Iowa case for fraud. This is a very significant development for the field. The suits focus both on medically unproven and non-FDA approved stem cells and exosomes. …Read More

3 min read

Here are our weekly recommended regenerative medicine and other notable science reads including a few things on COVID. It’s been quite an interesting week. “Junk DNA” is not so junky, role in differentiation NIH scientists showed how ancient retroviral genes, or “junk DNA”, may play a role in helping stem cells decide to become neurons. This work is from the Nath lab, NIH/NINDS. You can see a YouTube video above on the work and an artistic rendering of some of what the authors think is going …Read More

5 min read

The biotech Mesoblast is starting an expanded access study of its stem cell product for kids with a severe offshoot of COVID-19. The cellular drug in this case is remestemcel-L (more below). While most children fare better than adults in dealing with COVID-19, the rare subset of kids with COVID-19 for this study have more severe disease than the average COVID patient and some die. Physicians need more potential treatment options here for these children. In that sense one could argue that testing more new …Read More

3 min read

My lab’s new paper in Communications Biology focused on high-grade pediatric glioma that have mutant histone variant H3.3 and we did something fairly novel that we are calling reciprocal CRISPR. Kids with these tumors have a near zero survival rate within a few years of diagnosis so we as a field desperately need something new to give them and their families real hope. Our paper is entitled, “Reciprocal H3.3 gene editing identifies K27M and G34R mechanisms in pediatric glioma including NOTCH signaling.” What we did in …Read More

4 min read

What’s new in the stem cell, cell therapy, and regenerative medicine world as well as biomedical science more generally including cancer? There’s quite a bit of news as reflected in media pieces and new pubs. Today’s post is focused on pubs that just came out. For last week’s recommended reads see here. Oct4-Sox2 Nucleosome Binding & Impact in mESCs This is one of my favorite papers of 2020 so far, coming to us from Science. Mechanisms of OCT4-SOX2 motif readout on nucleosomes. I knew from …Read More

3 min read

Clinical trials using organoids are still rare and a Clinicaltrials.gov search for such organoid work largely brings up in vitro studies. A new clinical study in Japan where organoid material will actually be transplanted into patients is causing a lot of excitement. Masayo Takahashi (高橋 政代) is a pioneer in stem cell-based clinical trial work and more specifically induced pluripotent stem cell (IPSC)-based trials. Her new clinical study is another groundbreaking step in that it is organoid based, in this case for Retinitis pigmentosa. …Read More

1 min read

Note that this is post “সস্য কোষ (স্টেম সেল) কাকে বলে?” in Bengali is one part of our “Stem Cells Not Lost in Translation” series. You can see the full series of our stem cell white paper in the other 34 languages here. সস্য কোষ (স্টেম সেল) কাকে বলে? মানবদেহে শত শত বিভিন্ন ধরণের কোষ (সেল) রয়েছে যা আমাদের প্রতিদিনের স্বাস্থ্যের জন্য গুরুত্বপূর্ণ। এই কোষগুলি প্রতিদিন আমাদের দেহকে চালিত রাখার জন্য কাজ করে, যেমন আমাদের হৃদয় ধরফর করে, মস্তিষ্ক চিন্তা করে, কিডনি আমাদের রক্ত …Read More