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Perspectives as Charles Brenner challenges David Sinclair on longevity claims

January 7, 2025 / Professor Paul Knoepfler, Ph.D. / 2 Comments

Professor Charles Brenner of City of Hope does great research, but I also applaud his efforts against longevity hype. Recently, Brenner and James Timmons publicly questioned some of the work of Harvard Professor David Sinclair. It’s a notable case of academics intensely disagreeing in the public space. Background While it’s interesting, it’s also a somewhat […]

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Refreshing WSJ piece on longevity ‘guru’ David Sinclair

December 10, 2024 / Professor Paul Knoepfler, Ph.D. / 3 Comments

I’ve written before about concerns related to longevity research hype from Harvard professor David Sinclair. The media often eats up statements about longevity from Sinclair and a few other scientists in that space. There is also endless coverage of the latest exploits of wealthy health influencer Bryan Johnson. For that reason it was refreshing to

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Review of new David Sinclair paper, supplements & anti-aging glitz

July 18, 2023 / Professor Paul Knoepfler, Ph.D. / 8 Comments

Who is David Sinclair and why is he all over the media related to anti-aging efforts? This post is my effort to fact-check Sinclair’s statements in the context of the broader rejuvenation arena. In the process I also review his most recent paper from my view as a stem cell and cancer biologist interested in

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Weekly reads: oocytes from males, David Sinclair longevity inc, diabetes, He Jiankui

March 19, 2023 / Professor Paul Knoepfler, Ph.D. / Leave a Comment

A team led by Harvard professor David Sinclair had a recent Cell paper on reprogramming to fight aging that I reviewed here on The Niche. I thought the paper was exciting and important. Note that in vivo reprogramming was first done more than a decade ago. Sinclair did have a novel fast-forward aging method and overall

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Perspectives on David Sinclair anti-aging Cell pub & in vivo reprogramming

February 7, 2023 / Professor Paul Knoepfler, Ph.D. / 2 Comments

About twenty years ago a science story made big news of a so-called anti-aging Methuselah gene. Methuselah gene and anti-aging The claim was that this DNA conferred long life on people. Hence the name Methuselah, which refers to a man from the Bible who reportedly lived 969 years. The so-called Methuselah gene was at first not a

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Tech Bro Manifestos, AI, and the Future of Biology (& Stem Cells)

January 28, 2025 / Parmin Sedigh / 6 Comments

How seriously should we take tech bro manifestos? Also, what do the tech bros — the billionaires and centimillionaires who made their fortunes founding, running, or investing in tech companies — have to say specifically about the future of biology including regenerative medicine and stem cell research related to AI? A fair bit, as it

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Meet The Screamers Science Hype Awards 2024 nominees

December 26, 2024 / Professor Paul Knoepfler, Ph.D. / 2 Comments

Each year I give out The Screamers Awards. As far as I know it’s the only science hype award in the world. The Screamers Awards recognize extreme examples of science hype, most often by the media. The major focus is on the biomedical sciences, but other areas of science are eligible too. Last year, the

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Grading my 20 stem cell & regenerative medicine predictions for 2024

December 24, 2024 / Professor Paul Knoepfler, Ph.D. / 1 Comment

Did you predict the major events in the stem cell and regenerative medicine field this year? I tried and today’s post are the grades on my predictions. Prediction is a key part of being a scientist even if we may not think about it that much. For instance, we have to try to predict what

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25 stem cell & regenerative medicine predictions for 2025

December 17, 2024 / Professor Paul Knoepfler, Ph.D. / Leave a Comment

regenerative medicine, stem cell predictions

Toward the end of each year I make predictions for the stem cell and regenerative medicine field for the coming year. I’ve been doing this for more than a dozen years in various forms. In this post I’m looking at the (gene-edited, stemness enriched) tea leaves for 2025 for the regenerative arena. These predictions include

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Stanford’s Mike Snyder and wellness coach Tony Robbins together yield some puzzling research

September 25, 2024 / Professor Paul Knoepfler, Ph.D. / 3 Comments

Mike Snyder and Tony Robbins, Stanford Tony Robbins

What do you think of when I mention Stanford professor Mike Snyder and self-help guru Tony Robbins together? I would not necessarily have imagined them forming a connection but science is full of surprises. I’ve admired Snyder’s work in genetics for a long time. I’m most familiar these days with Robbins for his interest in

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