Search Results for: HongKui Deng

Recommend reads: CRISPR baby guy free, DNMT3, sperm, Editas, hearing loss, reprogramming

Dura et al sperm development

We often don’t think of them that way but reproductive cells like sperm and egg are also relatives of stem cells, and it turns out that there are stem cells that make the reproductive cells too like sperm stem cells. Sperm and germ cell stem cells DNMT3A-dependent DNA methylation is required for spermatogonial stem cells …

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New research on CRISPR gene-editing in stem cells, infographic

CRISPR-infographic-stem-cells_small

As a pivotal advance in the gene-editing field and timeline, CRISPR continues to be utilized for research on stem cells and human diseases. Today, I will explain some of the most notable recent findings in the stem cell-CRISPR field. To start things off, I have also created an infographic that briefly explains what CRISPR-Cas9 is, …

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Big stem cell news: dynamic duo of all-chemical direct reprogramming reports

Neurons-created-from-ciNSC

There’s some big, positive news on the stem cell front today. Two new innovative papers both by teams led by Sheng Ding of Gladstone Institutes with UCSF report all-chemical direct reprogramming of human somatic cells. Ding’s team took skin cells and by exposing them to cocktails of small molecules was able to turn them directly into …

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Jacob Hanna on Radically Deterministic Reprogramming @TMM2013

What is “radically deterministic” cellular reprogramming? Jacob Hanna’s lab recently published a very high profile Nature paper on nearly 100% efficient iPS cell formation based on targeting a factor called Mbd3. This super efficiency is a major departure from past reported efficiencies. This morning here at the Till & McCulloch Stem Cell Meeting in Banff, …

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Nominees for Stem Cell Person of the Year 2013: scientists, advocates, physicians, and the Pope

Nominations for Stem Cell Person of the Year 2013 closed last night and I ended up with a remarkable list of 30 nominees. I have included a few sentences about each one below, often taking verbiage directly from the nominator. The online voting on these nominees will start soon. The top vote getters will move …

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What do you think of all chemical reprogramming? Take our poll

How important is the new development of all chemical reprogramming to make iPS cells? The group led by Hongkui Deng at Peking University in Beijing reported in Science that they used 7 chemicals to make what appear to be mouse iPS cells. I’m hearing a wide range of opinions directly from people in the know. What’s …

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