People often ask me what is the most promising new cell therapy and while it is difficult to choose just one, I often highlight the promise of stem cells for diabetes. Here in the U.S., early data from diabetes clinical trials by Vertex look encouraging. Other teams worldwide are also working in this space and […]
We often don’t think of them that way but reproductive cells like sperm and egg are also relatives of stem cells, and it turns out that there are stem cells that make the reproductive cells too like sperm stem cells. Sperm and germ cell stem cells DNMT3A-dependent DNA methylation is required for spermatogonial stem cells
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As a pivotal advance in the gene-editing field and timeline, CRISPR continues to be utilized for research on stem cells and human diseases. Today, I will explain some of the most notable recent findings in the stem cell-CRISPR field. To start things off, I have also created an infographic that briefly explains what CRISPR-Cas9 is,
New research on CRISPR gene-editing in stem cells, infographic Read More »
What is direct reprogramming ? There’s some big, positive news on this stem cell front today. All chemical direct reprogramming Two new innovative papers both by teams led by Sheng Ding of Gladstone Institutes with UCSF report all-chemical direct reprogramming of human somatic cells. Ding’s team took skin cells and by exposing them to cocktails of
Big stem cell news: dynamic duo of all-chemical direct reprogramming reports Read More »
What is “radically deterministic” cellular reprogramming? Jacob Hanna’s lab recently published a very high profile Nature paper on nearly 100% efficient iPS cell formation based on targeting a factor called Mbd3. This super efficiency is a major departure from past reported efficiencies. This morning here at the Till & McCulloch Stem Cell Meeting in Banff,
Jacob Hanna on Radically Deterministic Reprogramming @TMM2013 Read More »
Nominations for Stem Cell Person of the Year 2013 closed last night and I ended up with a remarkable list of 30 nominees. I have included a few sentences about each one below, often taking verbiage directly from the nominator. The online voting on these nominees will start soon. The top vote getters will move
How important is the new development of all chemical reprogramming to make iPS cells? The group led by Hongkui Deng at Peking University in Beijing reported in Science that they used 7 chemicals to make what appear to be mouse iPS cells. I’m hearing a wide range of opinions directly from people in the know. What’s
What do you think of all chemical reprogramming? Take our poll Read More »