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Juan Carlos Izpisua Belmonte Cell Paper on Gene Editing for Mitochondrial Disease

April 23, 2015 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 2 Comments

The Juan Carlos Izpisua Belmonte group published a Cell paper today on using gene editing to reverse mutations associated with human mitochondrial disease. The paper is Reddy, et al. and is entitled, “Selective Elimination of Mitochondrial Mutations in the Germline by Genome Editing”. The authors report success using TALEN-based gene editing or mitochondrial-direct restriction enzyme (mito-ApaLI) …

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Weekly reads: Conception Bio & IVG, MYC, Stanford Prez resigns

July 23, 2023 July 22, 2023 / By Professor Paul Knoepfler, Ph.D. / Leave a Comment

The Bay Area biotech Conception Bio has an intriguing name. What does “conception” mean here? Scientists can make many things from stem cells. For example, lately I’ve written a lot about stem cell-based human embryo models. Another intriguing area is called in vitro gametogenesis or IVG, where Conception Bio is a leader. IVG means making …

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Altos Labs: mission, leadership, jobs, & CIRM

April 12, 2022 April 12, 2022 / By Professor Paul Knoepfler, Ph.D. / 3 Comments

At the beginning of the year I wrote about a new kind of biotech called Altos Labs. It’s very different in some ways from other institutions. I find it an intriguing research entity. Where do things stand now with Altos Labs a few months later? More information, new ideas, and questions have popped up in the …

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All about Altos Labs & its $3B cellular rejuvenation push

January 20, 2022 August 21, 2023 / By Professor Paul Knoepfler, Ph.D. / 2 Comments

I wrote briefly a few months ago about Altos Labs. It’s a new kind of biotech institute that is focused on cellular reprogramming. Now we know much more and it’s clear this is a huge deal. What’s in this article What is Altos Labs? | Cellular rejuvenation | Reprogramming oldness | Challenges | Altos Strategies | Analysis of …

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Weekly reads: Bezos & stem cells for anti-aging, Myc, more

September 12, 2021 September 12, 2021 / By Professor Paul Knoepfler, Ph.D. / 1 Comment

Stem cells may have anti-aging properties, but they are unlikely to be a real fountain of youth. Even so, people are obsessed with aging and stem cells regularly are thought of as “the ticket” for fighting aging. I’ll start today’s recommended reads with that topic and then go on to list some interesting papers of …

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Monkey human embryo chimera Cell paper: exciting, ethically complex direction

April 15, 2021 April 15, 2021 / By Professor Paul Knoepfler, Ph.D. / 5 Comments

A new Cell paper from an international team led by Juan Carlos Izpisua Belmonte pushes human embryo chimera embryo research further than ever before. It is both exciting work and raises many complex bioethics questions at the same time. What is a human embryo chimera? By way of background, chimeric human embryos contain a mixture …

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Can a Heart Repair Itself Via Stem Cells

November 5, 2020 June 6, 2022 / By Professor Paul Knoepfler, Ph.D. / 6 Comments

Can a heart repair itself via their own stem cells and do hearts have meaningful populations of stem cells? Science evolves Sometimes what we scientists all know to be true turns out later on to be wrong and there are clear instances of this in the stem cell field. For example for decades the dogma was …

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Highlights #FOGM18 Day 1: Data from Ancient Dirt, Genomics Dilemmas, CAR-T, & CRISPR

March 2, 2018 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 2 Comments

There are many genomics meetings out there these days, but The Future of Genomic Medicine meeting (#FOGM18) at Scripps in La Jolla is one of my favorites. This meeting is uniquely empowering. The people and the talks combine for a one-of-a-kind experience. The venue doesn’t hurt either at the Scripps Seaside Forum. The evening before the meeting …

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Perspectives on pig human chimera paper

January 26, 2017 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 12 Comments

A new paper focused on human and other chimeras just came out today in Cell reporting a number of findings, but most strikingly successful generation of human-pig chimeras in utero. The paper, entitled, “Interspecies Chimerism with Mammalian Pluripotent Stem Cells” describes various chimeras including mouse-rat ones, although those have previously been reported. This work comes …

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Mitalipov Nature pub review: IPSC & SCNT for mitochondrial disease

July 15, 2015 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 6 Comments

In a new, thought-provoking paper today in Nature, Shoukhrat Mitalipov and a multi-institutional team report a significant advance toward potential novel ways to treat mitochondrial diseases. What are these illnesses? Mitochondrial diseases are rare, but devastating disorders caused by genetic mutations. Today they are largely impossible to treat in meaningful ways other than palliative care. Some …

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