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Weekly reads: death in CRISPR trial, sickle cell, nose picking & dementia, epilepsy

November 6, 2022 November 5, 2022 / By Professor Paul Knoepfler, Ph.D. / Leave a Comment

As both a scientist who works on stem cells, cancer, and CRISPR, and a research advocate I’ve been fortunate to meet many patient advocates over the years. Some have been participants in clinical trials themselves. Benefits & risks of clinical trial participation It is very sobering to find out that a clinical trial participant has …

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Parkinson’s disease stem cell therapy research update

October 11, 2022 October 11, 2022 / By Professor Paul Knoepfler, Ph.D. / 1 Comment

When I first started The Niche more than a dozen years ago, I hoped we’d see a Parkinson’s disease stem cell therapy by now. A proven one. I was a little too optimistic back then. Now in 2022, I know much better how hard translation to the bedside can be in general. Still, I’m hopeful. …

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Hope on Parkinson’s front: Japan IPSC trial 1st patient

November 18, 2018 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 2 Comments

Fig-3i-Kikuchi-et-al.-Nature-2017-IPS-cell-Parkinsons-

In Parkinson’s Disease patients develop neurological dysfunction as they lose a special kind of brain cell called dopaminergic (or dopamine) neurons. While a number of different approaches to this disease have been studied for decades, nothing has proven particularly successful in slowing its progression. As a result there has been a big need for novel thinking …

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Ian Wilmut, who cloned Dolly, opens up about his Parkinson’s Disease

April 11, 2018 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 3 Comments

One of the most famous living biological scientists, Sir Ian Wilmut, just announced that he has Parkinson’s Disease. I wish him the best in dealing with this illness. Wilmut is very well-known for having cloned the first mammal, Dolly the Sheep. This work followed on the earlier breakthrough by Sir John Gurdon of cloning the …

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On the threshold of cell therapy for Parkinson’s disease

November 13, 2017 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 7 Comments

Dopamine-neurons-derived-from-a-Parkinsons-disease-patients-iPSCs-Tyrosine-hydroxylase-1

By Jeanne Loring There are ten million people in the world who have Parkinson’s disease. 125,000 of these are living in California. People with the disease often have to step away from their jobs because the main symptoms – tremor or freezing up of muscles – make it difficult to get through a whole day …

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How risky are stem cell trials for Parkinson’s beginning in China?

June 1, 2017 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 16 Comments

New human clinical trials using derivatives of pluripotent stem cells in China for Parkinson’s Disease (PD) have raised expectations and some eyebrows. PD is a neurodegenerative condition, sometimes diagnosed or followed by PET scans such as the one at left, characterized by loss of dopaminergic neurons leading to severe and sometimes life-threatening symptoms. Pluripotent stem …

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Diverse Stem Cell Person of the Year 2014 Award Finalists

October 23, 2014 December 22, 2023 / By Professor Paul Knoepfler, Ph.D. / 11 Comments

With more than 4,142 votes cast, the readers of this blog have chosen the top 12 finalists for the Stem Cell Person of the Year Award for 2014 from the 27 nominees. You can see the final vote tallies at left. The votes came from more than 50 countries with some interesting geographic patterns (I …

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Stem Cell Person of the Year Award 2014 Voting: Who Will Be Finalists?

October 15, 2014 December 22, 2023 / By Professor Paul Knoepfler, Ph.D.

With one week left to vote to pick the top 12 finalists for the Stem Cell Person of the Year 2014 Award, we have more than 2,800 votes in so far. From the top 12 vote-getters, I will choose the winner. This is the third year of this award. I self-fund this award out of …

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Stem Cell Person of the Year 2014 Award: Vote To Choose 12 Finalists

October 8, 2014 December 22, 2023 / By Professor Paul Knoepfler, Ph.D. / 4 Comments

Nominations have closed and we have more than two dozen nominations for Stem Cell Person of the Year 2014. It’s an exciting, diverse group including some news faces as well as nominees from years past as well. Happy Stem Cell Day! You can now vote for your choice for the top finalists in the poll …

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