Search Results for: Organoids

Stem cells & the philosopher’s stone, P53, thyroid organoids

philosopher's stone

I hadn’t remembered the history of the philosopher’s stone until reading a new review article about stem cells and aging. Here’s the article. Is the philosopher’s stone to rejuvenate blood stem cells an epigenetic regulator? Nature Aging. This preview kind of piece discusses how inhibiting a specific factor called PHF6 can “rejuvenate” HSCs in mice. …

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Weekly stem cell reads: bat stem cells, brainier organoids, more

bat stem cell

I’m working to send out a big grant on Tuesday so I’m busier than ever but a few stem cell and regenerative medicine stories caught my eye. I can’t write grants 24/7 without a few breaks although sometimes it feels like that’s what I’m doing. Bat stem cell derivation Pluripotent bat stem cells as a …

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Weekly reads: taste buds, organoids, good news on CRISPR safety

Taste buds diagram

As I’ve mentioned recently, it’s my busy time for medical school teaching and not long ago we did a GI lab that included one of my favorite structures in the course: taste buds. Taste buds The medical students seem fascinated with taste buds too. I can tell as their professor when something is particularly interesting …

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How brain organoids are transforming research

Human brain organoids Knoepfler Lab.

Organoids including brain organoids are an exciting, relatively new area of research. This technology is having a powerful impact on biomedical science, which is the focus of today’s post. What’s in this post Definition of organoids | Brain organoids | Challenges for mini-brains | Cutting edge cerebral organoids | References Definition of organoids and brain organoids …

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Weekly reads: Google, stem cells & MS, VSELs, ‘hairy’ organoids, MYC

stem cells differentiating into neurons and glia

It’s been quite a ride doing this blog on stem cells and other technologies for more than a dozen years. So far it seems like I’ll keep it going. A large part of the reason is because of people needing good information about our field. Those people include scientists and physicians but also many in …

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A look at “eyes on the brain organoids” Cell Stem Cell paper

brain organoids eyes

Sometimes a paper really catches your eye like a new Cell Stem Cell pub reporting eye-like structures grown on brain organoids. The paper is Human brain organoids assemble functionally integrated bilateral optic vesicles. Let’s take a quick look at this paper, its context, and the potential big-picture implications. Brain organoids with “eyes”? At first glance, …

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Weekly reads: badgers, organoids, The Onion, & more

A badger in Yellowstone Park. Photo Paul Knoepfler. Could you make organoids from one?

It’s been a little quiet here on The Niche for the past week as I was off in Yellowstone National Park, but I’m back with this week’s recommended weekly reads including a section on organoids. First, I want to share a nature pic from the trip. A highlight was encountering a badger in Lamar Valley …

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Weekly reads: embryo pubs stir things up, organoids crying, & more

organoids tear glands sm

This was an unusual week in that three papers in a sense collided together related to embryo production and growth, raising new research possibilities but also serious ethical questions. New research: what is an embryo & what is not? The first two Nature papers reported generating the most realistic models of human embryos from scratch …

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Regenerative reads: brain organoids, Clinicaltrials.gov change

brain organoids sm

Sometimes change takes a very long time, but with brain organoids or advocating for better information for patients at Clinicaltrials.gov, after waiting you can see some interesting developments.  These are two of the regenerative medicine stories of the week, along with some striking research papers. Clinicaltrials.gov Some of us have been advocating for improvements at …

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Dissecting that Neanderthal brain organoids Science pub

neanderthal human brain organoids

Organoids and especially brain organoids, which are made from pluripotent stem cells, are one of the most interesting developmental biology technologies of the last half a dozen or so years. Still some folks can’t help but get carried away when thinking about brain organoids it seems. A new Science paper from a team led by …

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