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Counterpoints to Lovell-Badge & Daley’s CRISPR baby rationales

February 11, 2019 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 5 Comments

Two prominent scientists, Robin Lovell-Badge and George Daley, have been amongst the most outspoken proponents of leaving the door open to heritable human genetic modification via CRISPR. While they each have articulated their reasons in somewhat different ways at times, their core reasons arguing in favor of future heritable CRISPR appear largely the same. In …

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World Stem Cell Summit Blogging: Daley Plenary Talk

December 3, 2012 February 1, 2021 / By Professor Paul Knoepfler, Ph.D.

George Daley stem cell field SWAT analysis. He argues that the biggest threats to the stem cell field are premature and illegitimate clinical applications. He stresses need for innovation including by surgeons but cautions strongly against rushing therapies.

Summary of George Daley talk on iPS cells today in Seattle

May 19, 2011 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 4 Comments

The best talk today was the keynote address by Dr. George Daley focused mostly on iPS cells. Dr. Daley is one of the world’s experts on iPS cells and pluripotent stem cells more generally. He covered many interesting elements of the iPS cell field including the genetic mutations that seem to occur during the reprogramming …

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Fact-checking VSEL stem cells & VSEL treatment

June 7, 2022 March 29, 2023 / By Professor Paul Knoepfler, Ph.D. / 5 Comments

A few people in the stem cell field keep arguing that adult pluripotent stem cells exist, including so-called “very small embryonic-like stem cells” or VSEL stem cells. These days the supposed cells are called VSELs or V-cells too. Only a handful of researchers have ever been able to report finding and studying these cells. Others …

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CRISPR baby moratorium grows likely with rising tide of support including from biotech

April 28, 2019 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / Leave a Comment

Trying to make a CRISPR baby any time soon would be a really bad idea. How bad? Last December 3rd I penned a piece for STAT News arguing for a moratorium on the heritable use of CRISPR in humans. This potential future, radical application of “gene editing” is now often colloquially referred to as “CRISPR …

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Movers & Shakers in Stem Cell & Regenerative Medicine Field

July 2, 2017 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 1 Comment

Stem Cell & Regenerative Medicine field researchers move around to different places fairly often. It is interesting to note trends and also see who received what kinds of awards and such. Below is a list of some recent movers and shakers. George Daley got the ISSCR Public Service Award (you can see other ISSCR Awards here). …

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Hunting for computational approaches for stem cells at ISSCR2017

June 20, 2017 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 7 Comments

By Cátia Bandeiras, PhD Student at University of Lisbon, Portugal and Massachusetts Institute of Technology. See tweets from the conference using #ISSCR2017 @apulgarita I just wrapped up my stay at the Annual Meeting of ISSCR 2017, which happened in Boston. I decided to take advantage of the fact that I am living in Boston at …

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NEJM paper links 3 blinded patients to US Stem Cell clinic

March 15, 2017 September 14, 2023 / By Professor Paul Knoepfler, Ph.D. / 11 Comments

stem-cells-eyes, stem cell therapy side effects.

Do three blinded US Stem Cell clinic patients with major or complete vision loss constitute a significant adverse outcome? I would say so and a new paper details how this happened apparently at a particular publically-traded South Florida stem cell clinic business. You can see the damaged retinas of one such patient below in an image …

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A nation of stem cell miracles? CNN puff piece on clinic patient & Trump blows it

March 9, 2017 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 1 Comment

Would you believe in a stem cell miracle? Sometimes the mainstream media stumbles in its coverage of the stem cell world and a recent CNN puff piece on a patient of stem cell clinic Celltex is a prime example of just how extreme this can get. The CNN piece focuses on a Celltex patient who self-reports perceived …

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STAP cells (stap細胞) are real deal says new Vacanti patent declaration

January 10, 2017 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 14 Comments

STAP is back? Really? No, I don’t believe so, but there’s an interesting development and twist on the STAP cell front. Just a few days ago on January 4, 2017 Dr. Charles Vacanti, the originator of the STAP cells concept, submitted a declaration to the USPTO affirming the belief that STAP cells are real and requesting that …

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