cancer

Should men get a PSA test for prostate cancer? Yes, but…..

cancer stem cells

Should men get a PSA test for prostate cancer? The same federal panel that recommended that women in their 40s not get routine mammograms has now come forth with the statement that PSA testing men for detection of prostate cancer should be stopped. I think it is not that simple and I still believe in …

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Cancer stem cells and iPS cells

cancer stem cells

Yesterday I ran a cancer stem cells meeting here at UC Davis School of Medicine. We had some great speakers and over 150 participants including our outstanding keynote speaker, Dr. Jeremy Rich, Director of Stem Cell Research at the Cleveland Clinic. One of the ideas percolating through the meeting was that during cancer development, there …

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Secret Not so Secret Recipe for Safer iPS cells

IPS cells, induced pluripotent stem cells, Knoepfler lab, stained for TRA-1-60, an ES cell marker., where do stem cells come from?

Just how tumorigenic are iPS cells?  The field really doesn’t know at this point. However, a steady stream of papers have raised red flag after red flag about genomic and epigenomic alterations/mutations that are linked to cancer. Of course, then there is the fact that all the genetic changes actually used to make reprogrammed cells …

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My Cancer: how I became an advocate too

IMG_0572

There is a kind of invisible cultural wall between patients such as cancer patients and biomedical scientists like me, but this wall does not have to exist and indeed it is a negative wall as patients, scientists, doctors, agencies, and advocates can achieve far more together than apart. But the wall is surprisingly strong. Last …

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Devil in the details: small oncogenic lesions in iPS cells & ESC

Loring-in-lab-1

Yesterday I wrote about how difficult it is to tell different cell lines apart, including normal stem cells and cancer stem cells, especially since some accumulate accumulate oncogenic mutations that may make them seem more similar. A new paper is coming out that makes this case on a genomic level. Tomorrow’s Cell Stem Cell edition …

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