November 26, 2020

The Niche

Knoepfler lab stem cell blog

CRISPR

2 min read

The House Subcommittee on Research and Technology on Tuesday held a CRISPR hearing: “The Science and Ethics of Genetically Engineered Human DNA”. At the meeting, CRISPR pioneer Dr. Jennifer Doudna gave testimony along with Dr. Victor Dzau who is the President of the Institute of Medicine (IOM) of the National Academy of Sciences (NAS), Dr. Elizabeth McNally who is Professor at Northwestern, and Dr. Jeffrey Kahn, a Professor and bioethicist at Johns Hopkins. A screenshot of Doudna testifying is shown above. Note that the …Read More

2 min read

As CRISPR gene editing technology has advanced in the last few years, the number of genetically modified animals made with this system has steadily increased. Some are very interesting and useful for science. At the same time especially when they are little, they can be very cute. A nickname is going around for these GM animals: CRISPR-y critters or CRISPR critters.. It turns out that there used be a breakfast cereal called Crispy Critters. It had a very odd looking mascot named Crispy with …Read More

4 min read

A decade ago I wrote an article in the journal Nature Biotechnology about the rise of a new gene editing technology called zinc finger nucleases (ZNF). It was one of those “drumbeat” discoveries: at the time, my sense was it would revolutionize how we deliver genes to cells and tissues, and profoundly change the way we think about gene therapy. I was partially right. Although ZNFs are now well along in clinical trials for HIV, successive advances in precision gene editing now include transcription …Read More

5 min read

Last Thursday I participated in a meeting at Stanford Law School on human germline genetic modification hosted by Hank Greely (pictured at left), Professor of Law and Genetics at Stanford. The meeting was entitled, “Human Germline Modification: Medicine, Science, Ethics, and Law”. The panel included in addition to Hank and me, the following speakers: Marcy Darnovsky, Executive Director of the Center for Genetics and Society (CGS); Christopher (Chris) Thomas Scott, Stanford Center for Biomedical Ethics, and Lynn M. Westphal, Professor of Obstetrics and Gynecology, Stanford University Medical School. …Read More