December 1, 2020

The Niche

Knoepfler lab stem cell blog

CRISPR

2 min read

We’ve all heard the human embryo editing rumors. There is a sense that human embryos have already been CRISPR’d. Rumors are rumors and they may mean not a whole lot, but there definitely is a huge buzz on this right now both in a positive sense and with concern. The excitement is over the power of this technology to do transformative things. The worry is that these papers might easily cross a line or if they are not done incredibly rigorously with unquestionable transparency, institutional …Read More

2 min read

CRISPR Cas9 is a relatively new, powerful approach to gene editing and genetic modification more generally. In the relatively short window of time in which this technology has been widely available for gene editing applications it has already evolved rapidly to become more powerful. Here are some new papers of interest on this technology. With many CRISPR papers every week these days there are probably other great papers too. What are your favorite recent papers in this area lately? How much off-site targeting is …Read More

2 min read

It seems like Fridays are always a good time for reflection. It’s not like the scientist’s week ends on Friday sad to say, but still at least we can pause momentarily TGIF style and reflect on the maelstrom that is our lives, while cracking open another diet Coke or pouring another cup of coffee. This week was a great one for getting into some intense discussions with other scientists both in person and electronically. CRISPR the talk of the biology town. Everyone is talking …Read More

3 min read

CRISPR Cas9 gene editing technology is a game changer on many levels both inside and soon outside the lab. There is a growing sense of urgency amongst biomedical scientists to take a proactive approach to current and future use of CRISPR gene editing technology in human germ cells and embryos. These concerns have been heightened by rumors of multiple papers currently in various stages of peer review that will reportedly describe CRISPR-mediated gene editing of human embryos. A number of scientists and scientific organizations have recently come …Read More