December 1, 2020

The Niche

Knoepfler lab stem cell blog

IPS cells

2 min read

Yesterday I wrote about how difficult it is to tell different cell lines apart, including normal stem cells and cancer stem cells, especially since some accumulate accumulate oncogenic mutations that may make them seem more similar. A new paper is coming out that makes this case on a genomic level. Tomorrow’s Cell Stem Cell edition includes a paper by a team of researchers led by Jeanne Loring that has identified relatively small genomic abnormalities in ESC and iPS cells. While both ESC and iPS …Read More

1 min read

Sheng Ding’s lab reports today in Cell Stem Cell (you can read it here) that they have replaced all genetic factors in a new iPS cell reprogramming method except Oct4. The other factors were replaced by chemical compounds. Thus, we continue a major transition in the iPS cell field away from genes and toward chemicals. This work is very exciting. Even with the advent of totally RNA-based iPS cell formation, progress toward a completely chemical approach is quite important. Many believe that an entirely …Read More

3 min read

If IPS cells are not ready for prime time, it is probably due to these three critical challenges for these amazing cells. TUMORIGENICITY Those of us who work with IPS cells are very excited about their potential for use in regenerative medicine therapies. One serious hurdle we have talked about in the past is tumorigenicity. COST Another hurdle that is far less discussed, but is equally critical, is the potential cost of IPS cell based therapies. The therapeutic advantage of IPS cells over ESC …Read More

2 min read

Update in 2020: Wow, a lot has changed since this post almost 10 years ago, but Cell Stem Cell remains the main publisher of IPS cell articles still. The young iPSC field has published a truly massive number of papers in just 4 years. Searching ISI Web of Knowledge for papers with titles reflecting iPSC research (not just those that mention iPS cells), we find 424 total iPS cell articles from 2006-present. Interestingly, 32 of them (7.5%) were published in a single journal, Cell …Read More