August 6, 2020

The Niche

Knoepfler lab stem cell blog

multiple sclerosis

2 min read

There is more good news from leading stem cell biotech Advanced Cell Technology (ACT) on preclinical rodent studies using stem cells to treat mice with an MS-like condition. They published a new paper in the journal Stem Cell Reports entitled “Human ESC-Derived MSCs Outperform Bone Marrow MSCs in the Treatment of an EAE Model of Multiple Sclerosis” by Wang, et al. Note added: there’s a related interesting paper from Jeanne Loring and Tom Lane’s groups in the same issue using neural progenitors made from …Read More

8 min read

Today’s post is my no-B.S. guide to the possibility of stem cells being used to treat Multiple Sclerosis (MS). There is a great deal of buzz about using stem cells to treat or even cure multiple sclerosis. How much of this stem cell buzz is real hope and how much is hype? MS has a host of symptoms (see illustration at left from Wikipedia). For many patients, conventional chemical medicines do a reasonable job managing the disease. However, for others the disease relapses, is …Read More

3 min read

Is Advanced Cell Technology (ACT) on the road to cure Multiple Sclerosis (MS) using stem cells and specifically MSCs? Some folks seem to think it’s quite possible, but I remain skeptical. Still there have been some interesting developments. ACT has a relatively new patent filing for a mesenchymal stromal cell (MSC) product that was just recently published. The filing has 125 claims. Wow. Mentioned prominently in the patent filing is MS as a target disease. In fact, there are rumors that ACT has already …Read More