October 24, 2020

The Niche

Knoepfler lab stem cell blog

STAP cells

4 min read

If you take an ordinary cucumber and soak it in a mild acid solution of vinegar for a few weeks you get a pickle, which is where we find STAP stem cells. Recently, some scientists reported in Nature that if you take ordinary cells and soak them in a mild acid solution for 30 minutes, often the cells transformed into the most powerful type of stem cells known to science. These newly incarnated pluripotent or totipotent stem cells, which they termed “STAP” stem cells, reportedly …Read More

2 min read

A new article in the major Japanese newspaper, Asahi Shimbun, just came out suggest major intellectual property (IP) and patent issues related to stem cells including the new stress induced STAP stem cells. The piece is entitled provocatively enough “Global patent war looms with epoch-making discovery of STAP cells“. That’s strong language. The article begins with an equally intense statement: Japanese researcher Haruko Obokata’s recent breakthrough in the creation of pluripotent stem cells in mice is set to trigger an all-out global patent war. Puzzlingly, the …Read More

5 min read

The recent publication of two Nature papers by a team in part led by Dr. Charles Vacanti on acid treatment produced stem cells (so-called STAP stem cells) has been a blockbuster story in the stem cell field and has grabbed major global media attention as well. For background my review of the paper here and more thoughts here. Many people understandably want to learn more about STAP stem cells.  For that reason, I invited Charles Vacanti to do an interview on my blog. Dr. Vacanti is Professor of Anaesthesia and head of …Read More

2 min read

The STAP papers on making iPS like cells using acid treatment of differentiated cells really has people talking. See embryo at right made from GFP reporter STAP cells that glow green. As I said in my review of the papers yesterday, there are still some critical things we do not know about STAP cells and I posed 6 key questions that remain open so we cannot really predict their impact quite yet or the impact of this technology. I will, however, make a few predictions …Read More