October 22, 2020

The Niche

Knoepfler lab stem cell blog

stem cells

2 min read

StemCells, Inc. is one of those stem cell-related biotech companies that we in the field hope will become a big success and help many patients in the future via stem cell technology. There are a lot of obstacles facing such companies. Some are privately held, while others such as StemCells, Inc. are publicly traded (stock symbol STEM). Unfortunately, StemCells, Inc. has had to face two rather serious problems in the last few weeks. First, former CIRM President Alan Trounson joined the leadership of StemCells, Inc. only days …Read More

2 min read

For more than 3 months I’ve been doing a tracking poll on the sentiments of the readers of this blog about STAP stem cells. The question is “Do you believe in STAP Stem Cells?” The result are summarized in the graph above. The latest poll results from period #9 are somewhat of a surprise. The overall trend for Poll #9 on STAP stem cells would seem to indicate a significant shift toward a more positive view, at least for the category “Close Yes”, meaning …Read More

4 min read

A simple proposal to make STAP protocols clearer 日本語版はこちら By Jun Seita Detection of a GFP signal driven by the Oct3/4 promoter was extensively used to define STAP cells in the original STAP papers [1, 2] and similar approaches have been employed by many third-party attempts to reproduce STAP cells. On the other hand, it is well known that stressed and/or damaged cells harbor significant auto-fluorescence. This is particularly pertinent to the case of STAP cells, because the various stresses applied to cells may …Read More

2 min read

What’s the latest on the now two-week-old STAP stem cell saga? More preliminary data from around the world.  People continue to deposit their data into our crowdsourcing page with 8 reports so far and I know some of them are from top-notch labs. Only one of them is even slightly encouraging with a report of faint activity from a Nanog-GFP reporter, while the rest are discouraging. It is still early days, but I think if nothing else so far these reports tell us that …Read More