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‘We Cannot Stick to the Rules’: claims of stem cells saving COVID-19 patients

March 3, 2020 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 13 Comments

I’ve been watching as the number of registered stem cell-related clinical trials for the novel coronavirus (SARS-CoV-2) disease COVID-19 continues to spiral upward, mostly in China. During the last two weeks, I’ve been trying to carve out a bit of time to look at these actual trials in more depth, but I admittedly haven’t gotten …

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COVID-19 stem cell trials pile up during novel coronavirus outbreak

February 19, 2020 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 15 Comments

Could stem cells help patients with the novel coronavirus disease COVID-19? It’s hard to say at this point. Is it worth doing trials during the outbreak to find out? Three new clinical studies have popped up on Clinicaltrials.gov investigating the potential of stem cells to help patients infected with the new coronavirus 2019-nCoV. Update, the …

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Probing F1 legend Michael Schumacher stem cell juice story

September 22, 2019 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 7 Comments

What’s the deal with Michael Schumacher and his Hail Mary stem cell procedure. Usually when we hear about celebrities getting unproven stem cells, it’s the celebrity themselves or their PR machine hyping it in exchange for something like free treatments or even money from those offering the stem cells for sale, but in the past …

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What is stromal vascular fraction or SVF?

July 21, 2019 December 1, 2023 / By Professor Paul Knoepfler, Ph.D. / 26 Comments

When people discuss “fat stem cells” they usually mean “stromal vascular fraction” or SVF. While references to fat or adipose stem cells can sometimes mean non-SVF materials, these days adipose SVF gets the most attention. But, does anyone have a clear picture of this biologic? Fortunately, it’s starting to come more into focus in recent years …

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Japan stem cell clinical studies rapidly piling up

March 17, 2019 December 22, 2023 / By Professor Paul Knoepfler, Ph.D. / 5 Comments

Shibata-et-al.-Cell-reports-2018-corneal-structures-made-from-hIPSCs

Japan is a leader in stem cell and regenerative medicine research, and in particular in clinical translation toward the bedside. Induced pluripotent stem cell (IPSC)-based investigational therapies are rightly an area of focus in Japan given their invention by Nobel Laureate Shinya Yamanaka. Small clinical studies based on IPSC have been initiated there for several …

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Japan’s dangerous gamble approving unproven stem cells for spinal cord injury

January 27, 2019 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 22 Comments

There is real hope for treating spinal cord injury with stem cell-based therapies in the future. However, unfortunately regulators in Japan have taken a major misstep in approving a not-ready-for-primetime mesenchymal stem cell (MSC)-based approach to spinal cord injury. Their decision is dangerous and unwise. In a Nature piece (linked to above) by David Cyranoski …

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Papers on artificial embryos and muscle stem cells

October 7, 2018 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 1 Comment

If you are sick of the general news lately, I recommend turning to the wonder of cool science like the thought-provoking data in the duo of new stem cell pubs discussed below including on artificial embryos. Synthetic embryos A team led by Alfonso Martinez-Arias reports new findings in their Nature letter in the growing area …

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Stem-ish cells: what’s the real thing?

June 17, 2018 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 5 Comments

Ain’t nothing like the real thing…right? No, by the ‘real thing’ I’m not talking about Coke versus Pepsi or Coke versus Diet Coke, but rather stem cells. (On a side note there’s still some people who apparently believe the stem cell myth that there are stem cells in Pepsi). I get a regular stream of …

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Stem cell clinic experimenting on patients with unapproved genetically modified ‘cancer vaccine’?

May 9, 2018 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 8 Comments

What if it seemed based on the public statements of its leader that a business was using an unapproved and unproven, genetically-modified, stem cell-based ‘cancer vaccine’ on patients? Is that possible? Sometimes I think I’ve seen and heard it all when it comes to companies marketing non-FDA approved, scientifically unproven stem cell ‘therapies’ to patients …

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Why did Texas A&M ink big deal with stem cell clinic firm Celltex on exosomes?

February 8, 2018 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 4 Comments

The recent news that Texas A&M University has inked a full-blown deal with the direct-to-consumer stem cell clinic firm Celltex struck me as an unusual development. Recently we’ve seen more universities exploring the use of stem cells outside of the traditional FDA clinical trial process that is fundamentally based on an investigational new drug application (IND). Some …

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