Search Results for: h3.3

Reciprocal CRISPR gene editing in pediatric glioma: defining mechanisms & testing drugs

February 1, 2021 / By / 1 Comment
reciprocal-CRISPR-mutant-H3.3

My lab’s new paper in Communications Biology focused on high-grade pediatric glioma that have mutant histone variant H3.3 and we did something fairly novel that we are calling reciprocal CRISPR. Kids with these tumors have a near zero survival rate within a few years of diagnosis so we as a field desperately need something new to give …

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Stem cell & other science weekend reads: arteries, diabetes, iffy metaphors, & more

February 1, 2021 / By / 1 Comment
weekend-reads-include-this-paper-from-Eric-Olsons-lab

What are your weekend reads? Many of us scientists read up on specific articles over the weekend that caught our eye during the last week or two. Here are some of my weekend reads plus some other stuff that just generally looked really interesting or unusual. The list includes both primary papers and news articles …

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Recommended recent stem cell, peds cancer & CRISPR reads

February 1, 2021 / By / Leave a Comment
dental-stem-cells

Here are some articles that look especially interesting on stem cells, cancer, and CRISPR. I was just at the SNO meeting in SFO on childhood brain tumors so those are on my mind more. Childhood cerebellar tumours mirror conserved fetal transcriptional programs (Nature) Childhood brain tumors “think” they are building organds in fetuses. H3.3 K27M depletion …

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TGIF Weekend Science Reads: stem cells, PRP, CIRM, CRISPR, & more

February 1, 2021 / By / 2 Comments
Sun-et-al-PNAS-2018-part-of-Fig-1

What do you read on the weekend? I wish for me it was at least in part some contemporary novel or science fiction, but that’s rare. More often than not it is almost all science. I do read the Sunday NY Times at least. I usually accumulate things during the week that I want to …

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Recommended Weekend Science Reads

February 1, 2021 / By

The pieces on my radar screen to read in my ample spare time as I work the weekend on literally 5 different grants include these pieces: NECSS and SfSBM: A weekend of science and skepticism Breaking Down Fat: Trends in adipose cell-based clinical trials PubPeer Selections: Odd citations, “practice makes perfect,” a Nature update Right Turn: …

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TGIF: Biomedical weekend reading includes some cool papers

February 1, 2021 / By / 6 Comments

TGIF: I’m working on an R01, but I still try to find time to read a wide variety of papers. Below are the science pubs that I’m hoping to get to this weekend. Less Myc, longer “health span” Cell paper from Sedivy Lab. ESC Histone H3.3 nucleosomal functions Epigenetics & Chromatin paper from Keji Zhao Lab. Human …

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What do sperm have to do with brain tumors?

February 1, 2021 / By
H3.3

Sometimes in science there are unexpected threads tying seemingly very different things together. Unraveling the knots in these threads can lead to new insights into important developmental processes and mechanisms of disease. My lab studies epigenomic and transcription factors including a molecule called histone variant H3.3 (more here on H3.3). H3.3 binds to the actual …

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