One question I am frequently asked by readers and colleagues is “what other stem cell blogs or bloggers can you recommend that are written by a stem cell scientist and updated on a regular basis?” The simple but surprising answer: there are none. It’s lonely out here in cyberspace! (2020 update: The good news today …
How many scientist bloggers does it take to change a light bulb? Read More »
Dr. James Sherley, the scientist behind the lawsuit against federally-funded ES cell research, has penned an opinion piece in The Daily Caller today calling on NIH to, in his words, ‘do the right thing.’ However, what Sherley is really asking is for the NIH, other stem cell scientists, and all Americans to think like he …
James Sherley of anti-ESC lawsuit calls on NIH to think like he does Read More »
The biotech Sarepta has had a complicated go of it with the FDA sometimes related to their Duchenne muscular dystrophy (DMD) gene therapy efforts. In late 2016 I wrote about how there was some controversy as the FDA approved the Sarepta drug eteplirsen (Exondys 51) also for DMD, going against an advisory panel that had …
Weekly reads: Sarepta, epigenomics, FDA on eyedrops Read More »
It’s always exciting when your lab has a new paper and my team just published a study knocking out the H3f3a gene in mice, which codes for histone H3.3 protein. We found that loss of this gene leads to lethality at a late stage of embryonic development. There were also indications of more specific phenotypes …
Weekly reads: H3.3 on the brain, Texas bill, HSCs Read More »
If you’ve never heard of the KRAS G12C mutation, it’s a particularly frightening mutation present in numerous cancers. Like the MYC oncogene, many people view mutations in RAS as undruggable, but new efforts show some glimmers of hope. The drug Sotorasib has been approved by the FDA to target the KRAS G12C mutation. Here’s a …
Weekly reads: KRAS G12C, eLife journal controversy, bird iPSCs Read More »
Organoids including brain organoids are an exciting, relatively new area of research. This technology is having a powerful impact on biomedical science, which is the focus of today’s post. What’s in this post Definition of organoids | Brain organoids | Challenges for mini-brains | Cutting edge cerebral organoids | References Definition of organoids and brain organoids …
Blastoids are lab-grown models of human embryos that represent a relatively new area of developmental biology research. The goal of today’s post is to give you everything you need to know about this topic. What’s in this article What are blastoids? | How are blastoids made? | Use in research | Blastoids challenges & Ethics …
What are blastoids, roles in biomedical research, & ethical considerations Read More »
Eight years ago two new Nature papers broke on the scene reporting supposed STAP cells with one of the senior authors, Charles Vacanti of Harvard, most well known previously for making the so-called “Vacanti mouse” along with his brother Joseph. The Vacanti mouse had a bioengineered human ear growing on its back. While STAP cells …
Recommended reads: Dux, 3D printed ear brings Vacanti mouse to mind, AMD, more Read More »
It’s very challenging to be an academic scientist even under normal circumstances so when a government starts going after researchers for things like supposed irregularities in funding disclosures, it can cause serious problems if not carefully overseen. We’ll start this week’s recommended reads with the feds monitoring such disclosures and even making referrals to the …
Weekly reads: Yale scientist suspended, WA AG sues clinic, new pubs Read More »
I’m taking a short break today from working on a big grant to put out this weekly reads post including on Sox transcription factors, cord blood paper controversy, and other interesting papers such as one on CTCF and chromatin domains after mitosis that really struck me. I can actually see blue sky today here in …
Weekly reads: CTCF, Sox transcription factors, Clinic fires back, more Read More »