Search Results for: cancer stem cell

Fountain Life update: lawsuit by doc, high performance aging, Celularity trial plan

January 18, 2024 / By / Leave a Comment
Fountain Life

A New Rochelle doctor has filed suit against the healthcare clinic firm Fountain Life alleging fraud. Now seems like a good time for an update on the firm. Peter Diamandis along with Bob Hariri, life coach Tony Robbins, and surgeon William Kapp founded Fountain Life, an early detection-focused healthcare company. Are they also a longevity firm? To …

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Weekly reads: Vertex & CRISPR Therapeutics, Arnold Caplan death, MS genetics

January 14, 2024 / By / 5 Comments
CRISPR Therapeutics

The biotechs Vertex and CRISPR Therapeutics have an interesting relationship as biotechs. They are partners are multiple levels but also are very different as companies including in size. There’s been a key development in one of their partnerships. Before we jump into that, please check out the video version of my 20 stem cell and …

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Can trying to cheat death paradoxically kill you sooner?

December 25, 2023 / By / 10 Comments
anti-aging, Dorian Gray

Can you paradoxically kill yourself early by trying to cheat Death? For example, die through risky anti-aging approaches? The question came to mind because such longevity efforts have become more extreme. They also get more hype in the media. I’ve been following the anti-aging space mainly because many interventions involve risky stem cell injections. Those …

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Biological age, health flexing, & stabs at rejuvenation

December 19, 2023 / By / 4 Comments
health flexing, biological age

We all know people who seem far younger than their age, which feeds into the idea of biological age. It’s often in the news these days and all over social media. Some people who are fighting high-profile battles with aging are also doing something I call “health flexing.” I also called these folks by another …

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Burst Biologics unapproved biologic used by Weill Cornell: was there a cover-up?

September 21, 2023 / By / 3 Comments
Burst Biologics, Christopher Jones

The New York Times just broke a story on Burst Biologics and Weill Cornell that fits with long-standing troubling questions about regenerative biologics producers. The story also bears on the doctors and hospitals like Weill Cornell that were or are customers of the suppliers. Further, what is the FDA’s role in all of this? The …

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Weekly reads: DNA methylation, H3 K27M in glioma, memory wipe, teeth

August 19, 2023 / By / Leave a Comment
DNA methylation

I’ve been more interested in histones and their modifications versus DNA methylation when it comes to epigenetics and chromatin. In part this has just been because I have studied histones so much more. For example, we have been knocking out the two histone variant H3.3 genes, H3f3a and H3f3b, now for a decade. My lab also …

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Review of new David Sinclair paper, supplements & anti-aging glitz

August 2, 2023 / By / 7 Comments
David sinclair, anti-aging

Who is David Sinclair and why is he all over the media related to anti-aging efforts? This post is my effort to fact-check Sinclair’s statements in the context of the broader rejuvenation arena. In the process I also review his most recent paper from my view as a stem cell and cancer biologist interested in …

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Weekly reads: gene therapy nod, Nature pub ethics, CRISPR LDL

May 20, 2023 / By / Leave a Comment
Multipotent & totipotent vs pluripotent stem cells, very early human embryos totipotent stem cells

Totipotency literally means all powerful, but it refers in biology to specific cells. These cells can make every type of cell in the body of an organism plus the extraembryonic tissues needed for development. This includes humans. So if you could reprogram human cells like blood or skin cells into totipotent stem cells, you might …

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Weekly reads: Sarepta, epigenomics, FDA on eyedrops

April 15, 2023 / By / Leave a Comment
Sarepa CEO interview.

The biotech Sarepta has had a complicated go of it with the FDA sometimes related to their Duchenne muscular dystrophy (DMD) gene therapy efforts. In late 2016 I wrote about how there was some controversy as the FDA approved the Sarepta drug eteplirsen (Exondys 51) also for DMD, going against an advisory panel that had …

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Trends in retractions as AI arms race on misconduct looms

April 14, 2023 / By / 3 Comments
stem cell paper retractions, retraction watch

There has been a big jump in paper retractions in science over the last 20 years. What’s going on? How do the trends in the stem cell field compare to other fields like cancer research and more broadly? Is AI going to change the dynamic between those engaging in misconduct and those who are looking for misconduct …

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