Search Results for: cancer stem cells

Knoepfler Lab Publications

2014 Epigenetic mechanisms of tumorigenicity manifesting in stem cells. Tung PY, Knoepfler PS. Oncogene. Jun 16;0. doi: 10.1038/onc.2014.172. [Epub ahead of print] Histone H3.3 regulates dynamic chromatin states during spermatogenesis. Yuen BT, Bush KM, Barrilleaux BL, Cotterman R, Knoepfler PS. Development. 2014 Aug 19. pii: dev.106450. [Epub ahead of print] Miz-1 Activates Gene Expression via a Novel Consensus DNA Binding Motif.. …

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Knoepfler Lab

The Knoepfler Lab conducts stem and cancer cell as well as chromatin/epigenetics research at the UC Davis School of Medicine. Our team has two big picture goals: (1) catalyzing the development of more effective treatments for cancers based on targeting stem cell-related machinery in tumorigenesis and (2) producing safer stem cell-based regenerative medicine therapies. We are particularly …

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Jacob Hanna on Radically Deterministic Reprogramming @TMM2013

What is “radically deterministic” cellular reprogramming? Jacob Hanna’s lab recently published a very high profile Nature paper on nearly 100% efficient iPS cell formation based on targeting a factor called Mbd3. This super efficiency is a major departure from past reported efficiencies. This morning here at the Till & McCulloch Stem Cell Meeting in Banff, …

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Was Einstein Wrong About Insanity?

Einstein

Was Einstein wrong on his definition of insanity? “Insanity”, said Einstein, “is doing the same thing over and over again and expecting different results.” But in science, how sane is it to expect experiments to give precisely the same results? How big a problem is irreproducibility in science? Experiments on that question have given variable …

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Where’s the Beef? Reality Check on Test Tube Burger Baloney

Mark-Post-of-Maastricht-University-UnVeiling-Test-Tube-Burger

What is the deal with the crazy hullaballoo over the so-called stem cell test tube burger? On the surface, this pseudo-burger sounds kinda cool in a geeky, comic book kind of way, but when I dug just a little deeper, it turns out I’m left asking: where’s the beef? After the burger was mentioned briefly on …

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What are VSELs and why are more clinics selling them?

One of the more controversial areas in the stem cell field has been over a stem cell type that only a handful of researchers have been able to find and study: very small embryonic-like stem cells or VSELs. These days some are calling them V-cells too. I’ve been getting an increasing number of questions from …

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FDA & Japanese Health Ministry (厚生労働省) To Develop Joint iPS cell clinical rules by 2015 while first human studies to begin earlier in 2014

In a rare sign of stem cell international regulatory unity, the Japanese Health Ministry (厚生労働省) and the US FDA have agreed to develop a joint, unified regulatory framework for clinical studies of human iPS cells for use in treating retinal diseases. Presumably the rules would also guide clinical use of iPS cells to treat other …

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BioTime CEO Mike West Interview Part 2: Geron & hESC

Michael-West-PhD-CEO-of-BioTime-1-934x10241

When you want to both know the real history of the pluripotent stem cell-based biotech industry and perspectives on its future, there are only a handful of people to turn to and one of them is definitely Dr. Michael West, CEO of BioTime. I’m doing a several part series of blog posts on a lengthy …

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Myriad SCOTUS Decision: Can you have a gene patent?

stem-cell-patent-300x2751

Should a company be able to have a gene patent and more generally and practically speaking can genes be patented? Patent and IP issues always raise a myriad of questions so what about a patent case on a company called Myriad? Complicated, right? If genes in their natural form cannot be patented, does that mean …

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