September 19, 2020

The Niche

Knoepfler lab stem cell blog

3 min read

The stem cell field is faced with a dilemma. Stem cells and some non-stem cells are sometimes too similar to tell apart. Even worse, stem cells and cancer cells are especially similar. If one focuses specifically on cancer stem cells (aka tumor initiating cells), the similarity between cancer stem cells and normal stem cells is even more pronounced. From the point of view of the old expression “if it walks like a duck and quacks like a duck, it must be a duck”, many …Read More

2 min read

In this post I give my prognostications about events in the stem cell field in 2011. Appeals court rules in favor of federally funded hESC research. This is more of a hope than a prediction, but I think there is a better than 50% chance of getting good news on this front. In either case, the decision is appealed to the Supreme Court. Will the Supremes hear the case? American support for federal funding of human ES cell research continues strong.Americans in 2011 more …Read More

1 min read

Advanced Cell Technology (ACT) announced that the FDA has approved their second human ES cell-based clinical trial, a combined Phase I/II, for the treatment of blindness. As a result, soon ACT will have two active, human ES cell-based clinical trials, both using the same human ES cell-based drug. The aim of the 2nd trial is to treat Dry Age-Related Macular Degeneration, a condition that affects tens of millions of people. The primary objective of both trials is to determine the safety of the stem …Read More

2 min read

Cancer patients and their doctors face daunting challenges at the time of diagnosis. Many crucial questions either cannot be answered or rely upon relatively low-tech methods whose accuracy is far from ideal. For example, how aggressive is this tumor? Has it already spread? After diagnosis and initial treatment, it is critical to monitor patients for recurrence, but for decades there have not been adequate tools to do this for most cancers. Thus, patients and their doctors are often left to wonder if their cancer …Read More