Search Results for: ES cell

ABCD Plan

Practical Plan for Managing Human Germline Genetic Modification CRISPR-Cas9 gene editing technology is a game changer on many levels both inside and soon outside the lab. There is a growing sense of urgency amongst biomedical scientists to take a proactive approach to current and future use of CRISPR technology in human germ cells and embryos. …

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Got that grant hamster wheel feeling?

EscherMobius

If you work in academia and on grants, hen you might have been getting that grant Möbius strip, hamster wheel, Groundhog Day kind of feeling… The funding rate for the key so-called “R01” NIH laboratory biomedical grant has never been lower. In the long run, R01s are crucial to the everyday running of most biomedical …

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Genetic Modification of Humans Now Inevitable?

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Discussion of concerns over heritable human genetic modification has spiked in 2015. This dialogue is a good thing, but is it in a sense too late? Are genetically modified (GM) people a foregone conclusion? Rumors are swirling that upwards of four papers reporting production of GM human embryos are in various stages of review at high-profile …

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Risks for Healthy PBSC Donors? One Family’s Powerful Experience

stem cell donor, where do stem cells come from?

By Jane Langille A few weeks ago, I wrote to Dr. Paul Knoepfler after reading his book Stem Cells: An Insider’s Guide because I was intrigued by his stem cell theory of aging. I wondered if his theory might mean that someone who mobilized and donated hematopoietic cells might be shortening their own lifetime supply. After …

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Lisa Ikemoto on Human Germline Genetic Modification

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This guest piece on Human Germline Genetic Modification is by Lisa C. Ikemoto, Professor, U.C. Davis School of Law. I have been following the reports about genetic editing technology with concern. The fact that some scientists are calling for moratoria on gene editing of human embryos heartens me. Frankly, I had little confidence that any …

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Practical Plan for Managing Human Germline CRISPR

ABCD-Plan-Human-Germline-Modification

CRISPR Cas9 gene editing technology is a game changer on many levels both inside and soon outside the lab. There is a growing sense of urgency amongst biomedical scientists to take a proactive approach to current and future use of CRISPR gene editing technology in human germ cells and embryos. These concerns have been heightened …

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David Baltimore, et al. path for human germline engineering

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In a new perspectives piece in Science, Nobel Laureate David Baltimore and co-authors including Jennifer Doudna and George Church, chart a potential path forward for human germline engineering. See also accompanying Bioethics piece by Gretchen Vogel as well, “Embryo engineering alarm”. In the piece, entitled “A prudent path forward for genomic engineering and germline gene …

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ISSCR calls for moratorium on clinical application of human germline nuclear genome editing

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The International Society for Stem Cell Research (ISSCR) just now released a new policy statement on human germline gene editing. The statement calls for a ban on clinical application of human germline gene editing technology. Here is the brief summary statement at the beginning: The International Society for Stem Cell Research calls for a moratorium on …

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Intensifying dialogue on human germline gene editing

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The field recently saw Lanphier, et al. in Nature calling for a moratorium on human germilne CRISPR genetic modification. A number of additional stakeholders are expected to be weighing in soon on the issue of human germline gene editing. For example, a Science paper from others in the gene editing community is anticipated soon and may well have somewhat different perspectives. I’ve been …

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