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GMO Sapiens book teaser: time to talk frankly on human genetic modification

October 23, 2015 / Professor Paul Knoepfler, Ph.D. / 2 Comments

I’ve written a new book on human genetic modification. This is my second book as the first one was Stem Cells: An Insider’s Guide, which is currently the top stem cell book on Amazon. The new book is called GMO Sapiens: The Life-Changing Science of Designer Babies. You can pre-order it here at Amazon or over here at my publisher’s […]

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Kelly Hills interview: human genetic modification & bioethics

August 20, 2015 / Professor Paul Knoepfler, Ph.D. / 5 Comments

Below is a conversation with bioethics commentator Kelly Hills (who BTW has a great blog), tackling some of the key issues surrounding the potential use of CRISPR-Cas9 technology to make heritable human genetic modification. I really appreciate her clear and insightful answers to some tough questions that many are grappling with today on this topic. Part

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Exciting CRISPR-powered “gene drive” also has scientists deeply concerned

August 12, 2015 / Professor Paul Knoepfler, Ph.D.

Scientists studying genetics are both excited and worried about a powerful, new technology called “gene drive“. Some have been raising serious concerns about gene drive and in certain cases calling for proactive regulation, which is unusual in science. This method is so powerful because it is designed to induce genetic changes in an entire population

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Doudna & Others Testify to Congress on CRISPR, Human Germline Editing

June 19, 2015 / Professor Paul Knoepfler, Ph.D. / 2 Comments

The House Subcommittee on Research and Technology on Tuesday held a CRISPR hearing: “The Science and Ethics of Genetically Engineered Human DNA”. At the meeting, CRISPR pioneer Dr. Jennifer Doudna gave testimony along with Dr. Victor Dzau who is the President of the Institute of Medicine (IOM) of the National Academy of Sciences (NAS), Dr.

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CRISPR critters: Cute pics of Cas9 gene edited animals

May 24, 2015 / Professor Paul Knoepfler, Ph.D. / 2 Comments

As CRISPR gene editing technology has advanced in the last few years, the number of genetically modified animals made with this system has steadily increased. Some are very interesting and useful for science. At the same time especially when they are little, they can be very cute. A nickname is going around for these GM

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News bites & rumors on human embryo genetic modification

April 30, 2015 / Professor Paul Knoepfler, Ph.D. / 8 Comments

A lot has happened in the week since the first human embryo genetic modification paper was published by a team led by Junjiu Huang. There have been a number of new events just in the last few days. Jocelyn Kaiser over at SCIENCEINSIDER has a new piece reporting a couple important developments including that the journal

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4 areas of debate on 1st human embryo genetic modification paper

April 27, 2015 / Professor Paul Knoepfler, Ph.D. / 5 Comments

Last week was a big one for the life sciences in that we saw the milestone of the first ever published paper reporting human embryo genetic modification (see here and here). It was one of those situations where we knew it was coming, but it was still a jolt. Not surprisingly this event sparked intense discussion

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Concerns surface on Chinese paper on genetic modification of human embryos

April 25, 2015 / Professor Paul Knoepfler, Ph.D. / 5 Comments

The paper that came out Wednesday from a research group in China reporting the first genetic modification of human embryos has sparked a lot of discussion. Some concerns about this paper have surfaced. 2-day review? The paper (HT to John Borghi) was in review only from March 30-April 1 — so at most 48 hours. Really? That certainly

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The big blind spot on CRISPR for human embryo editing: PGD

April 24, 2015 / Professor Paul Knoepfler, Ph.D. / 10 Comments

There is a big old blind spot in the discussion over germline gene editing in humans: preimplantation genetic diagnosis (PGD). There’s been a lot of talk in 2015 about worries over how gene editing technology such as CRISPR might be used prematurely in the clinic in an unsafe or unethical manner in humans in the

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Researchers in China make genetically modified human embryos

April 22, 2015 / Professor Paul Knoepfler, Ph.D. / 3 Comments

Rumors have been flying for months that researchers in China and possibly elsewhere were shopping papers around at high-profile journals that reported gene editing and genetic modification of human embryos. Update: apparently this paper (HT to @JohnBorghi) was only reviewed for 2 days (see image at bottom of post), raising major concerns about the depth of

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