Search Results for: arnold caplan

Weekly reads: Vertex & CRISPR Therapeutics, Arnold Caplan death, MS genetics

January 14, 2024 / By / 5 Comments
CRISPR Therapeutics

The biotechs Vertex and CRISPR Therapeutics have an interesting relationship as biotechs. They are partners are multiple levels but also are very different as companies including in size. There’s been a key development in one of their partnerships. Before we jump into that, please check out the video version of my 20 stem cell and …

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Interview with Arnold Caplan, Part 4: the FDA and the Future

February 1, 2021 / By / 2 Comments

Today is part of 4 (the last) of my interview with Dr. Arnold Caplan, MSC godfather and guru. You can read parts 1-3 of the interview here, here, and here. In this post I focus on my discussion with Caplan on translation of stem cells to patients and the FDA. During our conversation we talked about some …

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Interview with Arnold Caplan, Part 3: challenges & opportunities for clinical use of MSCs

February 1, 2021 / By / 5 Comments

I recently had a phone interview with Dr. Arnold Caplan, the founder of the MSC field. You can read parts 1 and 2 of the interview here and here. Today’s post, part 3, is focused on clinical use of MSCs. I want to start off today’s post with a wonderful quote from Caplan: “All MSCs …

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Insightful interview with Arnold Caplan: Part 1: MSC history, nomenclature, & properties

February 1, 2021 / By / 2 Comments

A few days ago I had a long, very enjoyable phone conversation with the father of the mesenchymal stem cells (MSC) field, Dr. Arnold Caplan. Dr. Caplan is Professor of Biology, Director Skeletal Research Center at Case Western. He coined the phrase “mesenchymal stem cell” in the late 1980s. I’m going to break the interview …

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Multipotent & totipotent vs pluripotent stem cells

April 20, 2023 / By / 3 Comments
Multipotent & totipotent vs pluripotent stem cells, very early human embryos totipotent stem cells

What’s the difference between multipotent stem cells, totipotent stem cells, and pluripotent stem cells? The goal of today’s post is to help you learn and be clear on the differences. What’s in this article Definition of stem cells |Totipotent vs pluripotent stem cells | Pluripotent stem cells | Multipotent stem cells | The best kind of stem …

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Mesenchymal cells or MSCs: definition, clinical potential, challenges

September 1, 2022 / By / 16 Comments
mesenchymal cells, MSCs, mesenchymal stem cells, multipotent stem cells

I confess that I’m old enough to remember when the acronym MSC stood unambiguously for “mesenchymal stem cells”, but should it refer to a broader term like “mesenchymal cells”? The field has moved in that direction. I think that’s the best way to go too and I’ll explain why. The goal of today’s post is …

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‘I’d need a drink’: WaPo deep dive on clinic firm Lung Health Institute

February 1, 2021 / By / 1 Comment
H-CYTE-Ann-Sells-Miller

Washington Post reporters William Wan and Laurie McGinley have a new piece on the unproven regenerative clinic firm the Lung Health Institute. This article has a number of surprises and new insights. Previously the Lung Health Institute was called just the Lung Institute. It was recently acquired by the publicly-traded company H-CYTE, stock symbol HCYT. In the …

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Placebo effect & “the fade” after stem cell clinic shots

February 1, 2021 / By / 18 Comments
placebo-effect-expectations-from-hype, science hype

Sometimes when I talk about possible placebo effects with fans of stem cell clinics I feel like placebo becomes akin to a bad word in the discussion. However, any kind of medical procedure can cause placebo effects in people. We’re all susceptible to it. I believe that many perceived positive outcomes at stem cell clinics …

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20 Nominees for Stem Cell Person of the Year 2016 Award

December 22, 2023 / By / 4 Comments
Stem-cell-person-of-the-year-award

I received a score of great nominations for the Stem Cell Person of the Year 2016 Award and have briefly described the twenty nominees below. The point of the award is to honor the top positive stem cell leader who specifically thinks outside the box and takes risks. I’ve started an on-line vote where you can vote once per day for …

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