Search Results for: cancer stem cells

Regenerative reads: brain organoids, Clinicaltrials.gov change

brain organoids sm

Sometimes change takes a very long time, but with brain organoids or advocating for better information for patients at Clinicaltrials.gov, after waiting you can see some interesting developments.  These are two of the regenerative medicine stories of the week, along with some striking research papers. Clinicaltrials.gov Some of us have been advocating for improvements at …

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The Niche reads: COVID, new INDs, clinic suits, papers

duan et al current biology 2021 fig 1b, The Niche recommended reads

Here are my recommended weekly reads for The Niche readership for early February 2021 including COVID-19 and stem cell lawsuit updates, papers, and more. How many papers do you end up reading each week or month these days? More or less than before the pandemic? COVID-19 updates New diabetes cases linked to covid-19, WaPo  ICYMI …

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Recommended reads: jobs, FDA letter, & The Niche new look

the body building fda letter the niche

During the week as I’m doing other stuff I keep my eyes open for interesting things to read, including over the weekend about stem cell research, COVID, CRISPR, and more for The Niche weekly recommended reads. This week a lot was going as we updated The Niche site to our new theme and format. I …

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Recommended reads: CRISPR for Sickle Cell, Parkinson’s, & more

victoria gray family crispr sickle cell b

I’m playing catch-up on some reading given how busy I’ve been and this includes a groundbreaking NEJM pub on CRISPR for Sickle Cell and Thalassemia. CRISPR for Sickle Cell From December, here’s the key paper in the NEJM: CRISPR-Cas9 Gene Editing for Sickle Cell Disease and β-Thalassemia. There’s a lot to like about this clinical …

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What is a teratoma tumor? Research & treatment

What is a teratoma? human stem cell teratoma knoepfler lab sm

Sometimes on The Niche or while teaching students as a professor here at UC Davis School of Medicine, I’ve been asked: What is a teratoma? Not all tumors are created equal and some like teratomas are particularly unusual. Exactly what is a teratoma tumor? Teratomas are germ cell tumors. What this means is that the …

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Weekly reads & paper of the week: gene-editing vs. aging

koblan et al 2020 nature gene editing progeria

The paper of the week reports using base-editing, a kind of gene-editing, to reverse mutations associated with rapid aging syndromes, generally called progeria, but there are a lot of other interesting pubs to recommend for reading this week. I go over it all in this post. Gene-editing to fight premature aging syndromes In vivo base …

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Recommended regenerative medicine reads: making eggs, retraction, freezing, more

hamazaki et al nature fig 2b induction of oocytes from es cells

What to read when there are almost an endless number of stem cell and regenerative medicine pubs? Here are some suggestions including what I would say is a very unusual Nature paper on making egg cells from stem cells. If this could be done safely with human cells all the way to functional eggs, would …

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Weekly The Niche reads: lab-grown embryos & thymus, more

es cells embryos matrigel the niche sm

Today’s The Niche recommended weekly reads post includes both primary papers and also a few media pieces. I’m especially interested in the first piece on making more complex embryo-like structures from ES cells. This is a long way from just making embryoid bodies or EBs. At the end of the post I discuss an article …

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Overview of IPS cell prospects for clinical impact

IPS-cell-clincial-trials-map

IPS cell research is a growing area of promise for regenerative medicine. These stem cells, also known as iPSCs or more formally as Induced Pluripotent Stem Cells, are engineered cells that are programmed to function the same way as embryonic stem cells. They can be differentiated into possibly any type of cell that is needed for …

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