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Stem cell & regenerative medicine good news including Fate Therapeutics

January 13, 2019 December 22, 2023 / By Professor Paul Knoepfler, Ph.D. / 6 Comments

In the past month or two there has been a steady stream of good news in the stem cell and regenerative medicine world. Here are three examples starting with Fate Therapeutics. Fate Therapeutics Fate Therapeutics announced the first US IND for an induced pluripotent stem cell (IPSC)-related product. Its cleared product, FT500, is an off-the-shelf …

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24 cell therapy & stem cell stocks I’m following

February 23, 2021 August 12, 2022 / By Professor Paul Knoepfler, Ph.D. / 5 Comments

Stem cell stocks, meaning cellular therapy biotech companies, face many challenges, but their clinical research is crucial. Stem cell biotechs These biotechs have ups and downs, sometimes at the same time. This is kind of the standard of “life” as any biotech company. It is definitely the case in the volatile stem cell and cell …

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What are induced pluripotent stem cells or IPS cells?

January 25, 2021 May 31, 2023 / By Professor Paul Knoepfler, Ph.D. / 6 Comments

induced pluripotent stem cells clinical trials map

Induced pluripotent stem cells or iPS cells just might be the most exciting development in the stem cell field over the last 15 years. They have unique potential for clinical impact for regenerative medicine too. This may manifest both through their use to produce differentiated cellular therapies and indirectly via disease modeling as well as …

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Overview of IPS cell prospects for clinical impact

October 27, 2020 June 8, 2022 / By Suhas Sakamuri / Leave a Comment

IPS cell research is a growing area of promise for regenerative medicine. These stem cells, also known as iPSCs or more formally as Induced Pluripotent Stem Cells, are engineered cells that are programmed to function the same way as embryonic stem cells. They can be differentiated into possibly any type of cell that is needed for …

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CAR-T cells review: cancer & a critical look at possible uses in aging & COVID-19

September 3, 2020 June 8, 2022 / By Suhas Sakamuri / 2 Comments

Introduction to CAR-T cells CAR-T cells are an exciting cutting-edge technology that has been garnering great interest including in the stem cell field. Potential therapeutic uses of CAR-T, which stands for Chimeric Antigen Receptor T-Cells (CAR-T), are being studied in clinical trials as immunotherapies to potentially fight cancer as well as many other diseases by …

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Stem cell reads: IPS cells, p53, mini-livers, baldness

June 7, 2020 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / Leave a Comment

We’ve had another week of interesting stem cell news and papers. Here is an aggregate of the stem cell and regenerative medicine week that was. Stem cell therapy for baldness I’ve covered stem cells for hair loss for about a decade here on The Niche. While it seems like it’s taken a long time for …

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Stem cell good news: novel cancer work, new CA bills, Alzheimer’s, & more pubs

April 8, 2019 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 1 Comment

There’s nothing like stem cell good news and interesting publications to perk one up on a Monday. Enjoy. What recent papers have struck you as exciting? Novel stem cell-based cancer approaches (Part 1) It was exciting when Fate Therapeutics got the first induced pluripotent stem cell (IPSC) IND in the U.S. for their IPSC-derived natural killer cell …

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Good final grades on my 20 x 2018 stem cell predictions

December 26, 2018 December 22, 2023 / By Professor Paul Knoepfler, Ph.D. / 1 Comment

Each year I make a list of stem cell predictions for the following year and I’ll release my predictions for 2019 soon, but first I’m grading how my 20 predictions for 2018 turned out. It seems I did better than usual predicting what would happen this year. I only got a couple partial credit or …

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Updated FDA granted RMAT List (85)

Today’s post includes a list of firms/products that have self-reported that they have received FDA regenerative medicine advanced therapy designation or RMAT. Sometimes people call these “r mat” with a space. As of December 12, 2023 there are 85 RMATs in the public domain. I also include FDA data on RMAT submissions via an FDA RMAT resource …

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