Happy St. Patrick’s Day! How might you celebrate? At least in part you might consider supporting St. Baldrick’s, which is a wonderful foundation that supports research on children’s cancer. Every year they have a very cool event where supporters of the organization get their heads shaved to raise money for the cancer research. In the past …
How Baldness Helps Toward a Cure for Children’s Cancer Read More »
I believe that social media has on the whole had a strongly positive impact on the STAP cell situation that the stem cell field has been grappling with for 5 weeks. If the STAP method is proven to be correct at some later date, which is possible, it’s almost certain that those replication efforts will …
Social Media Helps Field Deal With Stressful STAP Stem Cell Situation Read More »
Two of my favorite things are stem cells and histones. When they both come together in one paper and it’s in my favorite journal, Cell Stem Cell, you’ve got my full attention. My own lab is especially interested in the roles of histones and Myc in stem cells. So when I saw a paper a paper from …
Cool Cell Stem Cell Paper From Ishii Team on Histones & Reprogramming Read More »
Vad är stamceller? Den mänskliga kroppen innehåller hundratals olika celltyper, som alla spelar en viktig roll för vår hälsa. Cellerna gör så att våra kroppar fungerar som de ska genom att se till så att hjärtat slår, att hjärnan tänker, att njurarna renar vårt blod, att hudceller ersätts när de dör, osv. Stamceller har det …
2014 Epigenetic mechanisms of tumorigenicity manifesting in stem cells. Tung PY, Knoepfler PS. Oncogene. Jun 16;0. doi: 10.1038/onc.2014.172. [Epub ahead of print] Histone H3.3 regulates dynamic chromatin states during spermatogenesis. Yuen BT, Bush KM, Barrilleaux BL, Cotterman R, Knoepfler PS. Development. 2014 Aug 19. pii: dev.106450. [Epub ahead of print] Miz-1 Activates Gene Expression via a Novel Consensus DNA Binding Motif.. …
The Knoepfler Lab conducts stem and cancer cell as well as chromatin/epigenetics research at the UC Davis School of Medicine. Our team has two big picture goals: (1) catalyzing the development of more effective treatments for cancers based on targeting stem cell-related machinery in tumorigenesis and (2) producing safer stem cell-based regenerative medicine therapies. We are particularly …
A team at the Weizmann Institute of Science in Israel led by Jacob Hanna reports today near perfect reprogramming efficiency to make induced pluripotent stem cells (iPSCs) by eliminating a single factor called Mbd3 from the cellular equation. On first glance, the Nature article (Rais, et al.) seems to be all about boosting cellular reprogramming efficiency to close …
100% reprogramming efficiency reports Jacob Hanna Read More »
What if you could reprogram cells inside of an organism to a different fate and, for instance, make IPS cells? We can, right? But when most of us think about making induced pluripotent stem (iPS) cells, we imagine it all happening in a little plastic dish in our labs or in our colleague’s labs, not …
Stem cell journal club: dishing on Nature paper on making iPS cells inside mice Read More »
What is the deal with the crazy hullaballoo over the so-called stem cell test tube burger? On the surface, this pseudo-burger sounds kinda cool in a geeky, comic book kind of way, but when I dug just a little deeper, it turns out I’m left asking: where’s the beef? After the burger was mentioned briefly on …
Where’s the Beef? Reality Check on Test Tube Burger Baloney Read More »
An NIH and CIRM-funded postdoctoral fellow position in the Knoepfler Lab at UC Davis School of Medicine is open. The focus of research will be on the epigenomic functions of Myc and other chromatin regulatory factors in human iPS cells and ES cells. Preference will be given to applicants who do not already have postdoctoral experience, but …
Stem Cell Job Opening: Post-Doc in Knoepfler Lab at UC Davis School of Medicine Read More »