Search Results for: myc

Allis lab Science paper on histone H3.3 in pediatric brain cancer

Allis-H3.3-paper-165x3001

It has been fascinating in the last year to see the unfolding story of mutations in histone variant H3.3 in pediatric glioblastoma and related tumors. It seems amazing that in just over a year, a whole new area of cancer research has rapidly progressed. As I discussed in a recent post, histone H3.3 is a …

Allis lab Science paper on histone H3.3 in pediatric brain cancer Read More »

Taboo topics about iPS cells: updated for 2013

elephant-in-the-lab-covid-19-lab-ramp-up

I’m doing this series called “The Elephant in the Lab” where I discuss controversial or taboo laboratory topics that people are usually too afraid to publicly discuss.  I started with iPS cells (for a description and definition of iPS cells go here) and now have updated this post for 2013 because the field is changing rapidly. iPS …

Taboo topics about iPS cells: updated for 2013 Read More »

Are iPS cells being rushed to the clinic or has their time come?

The iPS cell field has run fast and furious over the past 6 years reaching a big milestone surprisingly quickly on Monday with Shinya Yamanaka winning the Nobel Prize. But is  the field going too fast? In August I argued that iPS cells are not quite ready for primetime (i.e. clinical trial studies). Now in …

Are iPS cells being rushed to the clinic or has their time come? Read More »

iPS cells are similar to cancer cells: part 1 of discussion of new paper

My lab just published a somewhat provocative paper (still in unproofed form at this point) arguing that iPS cells are very similar in some ways to cancer cells. How did we get to that conclusion (discussed in this post today, part 1 of the story) and what’s the back story on this paper (discussed in a later …

iPS cells are similar to cancer cells: part 1 of discussion of new paper Read More »

New medulloblastoma paper suggests novel avenues to treat this childhood cancer

Medulloblastoma is the most common pediatric brain tumor. However, treatments for children who are diagnosed with so-called medullos have not evolved much over the years and are largely similar to treatments given to adults for other brain tumors. One frequent event in certain medullos is amplification of two members  of the MYC family of oncogenes …

New medulloblastoma paper suggests novel avenues to treat this childhood cancer Read More »

What are the best iPS cell papers so far?

ipscellpapers

What are the most important iPS cell papers so far? 1) Yamanaka’s first paper on mouse iPS cells. Revolutionary. Intriguing perspectives presented in day 1 of the iPS cell field. Interesting statements such as Myc is required. Also take a look at those other reprogramming factors that he tested…there’s a tremendous amount there, largely unexamined. …

What are the best iPS cell papers so far? Read More »

Taboo topics about iPS cells: the elephant in the lab series

elephant-in-the-lab-covid-19-lab-ramp-up

Wait, what’s that taboo elephant doing in the IPS cell lab? You don’t see it? I’m starting a new series called “The Elephant in the Lab” where I discuss controversial laboratory topics that people are usually too afraid to publicly discuss. We are starting with iPS cells. (for a description and definition of iPS cells …

Taboo topics about iPS cells: the elephant in the lab series Read More »