3-person IVF

Paris human gene editing workshop summary

Académie-Nationale-de-Médicine

Editors note: This is a guest post from Caroline Simons who is attending the two Paris meetings on human gene editing. For more background on those meetings see here. By Caroline Simons There were just over a hundred participants at the workshop organized by the Federation of European Academies of Medicine, the UK Academy of …

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New chat with George Church on CRISPR’ing people, Zika, weapons, & more

George-Church

I talked last year about human genetic modification by CRISPR with George Church a year ago. Now we’ve followed up with a long chat on this topic going into much more detail and with questions on recent developments. Each question is listed numerically and then there is a back and forth on that question with George …

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Mitalipov Nature pub review: IPSC & SCNT for mitochondrial disease

Mitalipov-IPSC-paper

In a new, thought-provoking paper today in Nature, Shoukhrat Mitalipov and a multi-institutional team report a significant advance toward potential novel ways to treat mitochondrial diseases. What are these illnesses? Mitochondrial diseases are rare, but devastating disorders caused by genetic mutations. Today they are largely impossible to treat in meaningful ways other than palliative care. Some …

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250,000-fold oversight on 3-person IVF mitochondrial transfer?

mitochondrial-genes

Remember the debate over so-called 3-person IVF? The goal of this technology, also referred to as mitochondrial transfer and 3-parent IVF, is to prevent mitochondrial disease through nuclear transfer in oocytes or one-cell embryos. The resulting genetically modified (GM) human embryos and ultimately children if it works could have dodged mitochondrial disease, but also could have serious or …

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Juan Carlos Izpisua Belmonte Cell Paper on Gene Editing for Mitochondrial Disease

Figure-6B

The Juan Carlos Izpisua Belmonte group published a Cell paper today on using gene editing to reverse mutations associated with human mitochondrial disease. The paper is Reddy, et al. and is entitled, “Selective Elimination of Mitochondrial Mutations in the Germline by Genome Editing”. The authors report success using TALEN-based gene editing or mitochondrial-direct restriction enzyme (mito-ApaLI) …

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Genetic Modification of Humans Now Inevitable?

egg-edit

Discussion of concerns over heritable human genetic modification has spiked in 2015. This dialogue is a good thing, but is it in a sense too late? Are genetically modified (GM) people a foregone conclusion? Rumors are swirling that upwards of four papers reporting production of GM human embryos are in various stages of review at high-profile …

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George Church on Germline Human Genetic Modification

George-Church

I recently interviewed leading genomics scientist George Church on the ways that trends in genomics are changing our world and the possibility of heritable human genetic modification. His answers suggest that genomics and gene editing are poised to radically change our world and to literally change us. Here’s the George Church interview you’ve all been waiting …

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Monday, March 2: My Reddit AMA on 3-Person IVF – Mitochondrial Transfer

reddit-logo

On Monday, I’ll be doing another Reddit AMA, this time on 3-person IVF also known as 3-parent IVF, mitochondrial transfer, 3-parent babies, etc. You can see the upcoming AMAs including mine listed in the right sidebar here. Mine will start at 10AM PST/1PM EST. I hope to discuss with a wide audience all the key …

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