Allan Bradley

Mulling over latest CRISPR tumult, this one from Nat Biot pub on DNA lesions

July 17, 2018 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 4 Comments

If it seems to you like dramatic cautionary tales about CRISPR accompanied by all sorts of media are coming at us more frequently, it’s not your imagination. In the latest yesterday, it was reported in a new paper led by Allan Bradley that CRISPR-Cas9 results in sometimes large-scale chromosomal lesions at or even away from the …

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Doubts raised on key points of Nature paper on CRISPR gene editing of human embryos

August 30, 2017 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 11 Comments

Is it possible that CRISPR gene editing actually didn’t happen in many of the human embryos in that big Nature paper that made such news a couple weeks back? Some doubts have emerged that call the main conclusions of the paper into question and argue that more definitive studies are needed to be sure. An …

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