January 19, 2021

The Niche

Trusted stem cell blog & resources

Allis Lewis

3 min read

It has been fascinating in the last year to see the unfolding story of mutations in histone variant H3.3 in pediatric glioblastoma and related tumors. It seems amazing that in just over a year, a whole new area of cancer research has rapidly progressed. As I discussed in a recent post, histone H3.3 is a fascinating molecule that plays critical roles in regulating cellular chromatin and epigenomic states. H3.3 is, as mentioned above, also frequently mutated in some of the worst childhood brain tumors. …Read More