September 23, 2020

The Niche

Knoepfler lab stem cell blog

Alzheimer’s Disease

2 min read

Here are some articles that look especially interesting on stem cells, cancer, and CRISPR. I was just at the SNO meeting in SFO on childhood brain tumors so those are on my mind more. Childhood cerebellar tumours mirror conserved fetal transcriptional programs (Nature) Childhood brain tumors “think” they are building organds in fetuses. H3.3 K27M depletion increases differentiation and extends latency of diffuse intrinsic pontine glioma growth in vivo. (Acta Neuropathologica) from Suzy Baker-led team. H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and …Read More

3 min read

Below is an excerpt focused on Alzheimer’s Disease from my new book on stem cells. Stem Cells: An Insider’s Guide, which is targeted to a broad audience of people interested in stem cells. Alzheimer’s Disease (AD) is one of the most devastating illnesses. It destroys the brain, which shrinks over time (see image from Wikipedia at left) as the disease progresses. The toll of AD is not only measured in hundreds of billions of dollars in health care costs and millions of deaths, but …Read More

4 min read

UPDATE: I have added more discussion at the bottom about therapeutics and how regenerative medicine might work for Alzheimer’s Disease. Alzheimer’s Disease (AD) is the most common cause of dementia throughout the world, affecting 10s of millions of people. The cost to society is staggering and on a personal level for those of us who have had relatives with the disease, the personal fallout is just as enormous.  The last week has seen some very exciting news about research into AD giving more reason …Read More