September 18, 2020

The Niche

Knoepfler lab stem cell blog

Andy W. C. Pang

2 min read

Over the years some scientists including yours truly have expressed concerns about the possibility that mutations could crop up during the reprogramming process to make induced pluripotent stem cells (IPS cells or IPSC). How concerned should we be about IPS cell mutations? A cool new paper, Bhutani, et al, in Nature Communications from a team led by Jeanne Loring and Nicholas J. Schork presents data arguing against significant oncogenic mutations occurring during reprogramming to make IPSC. The authors summarize their findings this way: “Our results show a moderate …Read More