July 11, 2020

The Niche

Knoepfler lab stem cell blog

Betatrophin

2 min read

All the recent high-profile papers that are having troubles are bumming me out, with the latest example being the “Betatrophin” Diabetes paper from Harvard last year. Yesterday it was called into major doubt by a new Cell paper from a group led by Jesper Gromada at Regeneron. The authors of the original 2013 Betatrophin paper–Doug Melton’s team at Harvard– indicated in their own accompanying, somber perspectives piece also in yesterday’s issue of Cell that they agree that their 2013 report was largely incorrect. This unfortunate turn of events is based on both …Read More

1 min read

UPDATE: Unfortunately the Betatrophin paper discussed here originally back in 2013 has now largely been proven to have come to incorrect conclusions (for more read this). I finally got a chance to read the Cell paper by the Melton team on Betatrophin and it is quite cool. I think one big question is whether this can this be translated into humans, but it seems very encouraging. Another question is whether Betatrophin or some derivative when given as a chemical pill to patients could help control …Read More

2 min read

UPDATE: Unfortunately the Betatrophin paper discussed here originally back in 2013 has now largely been proven to have come to incorrect conclusions (for more read this). Today Harvard Stem Cell Institute (HSCI) reported the discovery, in a paper in Cell by Harvard Professor Doug Melton, of a powerful new hormone called Betatrophin that can stimulate growth of beta cells in vivo. Beta cells are the type of cell that are lost in Diabetes. From the HSCI press release: The hormone, called betatrophin, causes mice …Read More

3 min read

Harvard Stem Cell Institute (HSCI) is making a big announcement today about stems, the biggest they say in their almost decade-long existence. Last night I speculated/predicted some possible announcements. Today I’m betting they will announce the discovery of a novel factor called Betatrophin. More on Betatrophin in a minute, but first why do I think it most likely that their announcement is on it? In reality, I’m still not sure, but I suspect it is Betatrophin because I was alerted to a perhaps premature …Read More