September 26, 2020

The Niche

Knoepfler lab stem cell blog

brain stem cells

2 min read

It’s been a cool week for stem cell and other associated kinds of research. In this post I have a series of links to a variety of interesting developments and papers. Gene therapy cures bubble boy infants. William Wan over at the WaPo on this good news. Nope, this wasn’t done with CRISPR, but rather with a viral transgene approach (not TALENs as I mistakenly had originally written here). “The pigs were dead. But four hours later, scientists restored cellular functions in their brains”. This …Read More

3 min read

In a stunner, Harvard and Brigham & Women’s Hospital reportedly have jointly called for the retraction of 31 papers on heart stem cell research authored by embattled heart stem cell researcher Piero Anversa. The scoop on this by STAT/Retraction Watch written by Ivan Oransky and Adam Marcus gives further details on this mess and past travails of Anversa. He was the prime proponent of the idea of endogenous heart stem cells in adults, but things have gone south since his prime time as a …Read More

3 min read

Can we humans grow healthy new brain cells as adults and during later aging? The answer to this question is a big deal because it could have major impact on aging. Those hoped-for new brain cells could keep our brains functionally younger. Who doesn’t want to slow down the aging of their brain, right? Slowing down aging of the brain via new cell growth more broadly would have major impacts on society. Researchers have gone back and forth on this over years. Fairly long …Read More

5 min read

Is there a stem cell connection between the brain and aging? Could a type of brain stem cell control whole body aging? A recent big Nature article from the lab of Dongcheng Cai argues an emphatic “Yes” to these questions, at least in mice. In the Zhang, et al paper, entitled “Hypothalamic stem cells control ageing speed partly through exosomal miRNAs”, their team reports the claim that a narrow population of hypothalamic stem cells are directly fighting aging of the entire murine body via a …Read More