October 19, 2020

The Niche

Knoepfler lab stem cell blog

Brigham and Women’s Hospital STAP

3 min read

The STAP cell mess that began in January of this year has in some ways quieted down. In a broader sense, I believe that STAP is now and will be in the future viewed as a scandal that revealed some less than ideal aspects to the world of biomedical science and publishing. Where does this all stand today? A New STAP-Like Paper? The most recent development is the publication of a new paper pointed out by a number of people to me as perhaps STAP-like. …Read More

3 min read

A paper has been published reporting that repeated attempts to make so-called “acid bath stem cells” have failed. At the end of January it was claimed in two Nature papers that a mild acid treatment created pluripotent or even totipotent stem cells that that the authors termed “STAP cells” or “STAP stem cells” (collectively referred to here as “STAP cells” in this post). I reviewed the papers here on the blog when they came out and raised key questions about them. Since that time …Read More

2 min read

Whether STAP cells are real or baloney, much went wrong with the actual STAP cell Nature papers and the research reported in them by Obokata and her co-authors. Who is responsible for these two deeply flawed papers? I’m not sure we have enough information at this time to know definitively how responsibility/blame should be apportioned, but first author Dr. Haruko Obokata has so far received the lion’s share of the blame. Is that just? Her institution RIKEN seems to be placing almost all of the …Read More

1 min read

What’s up with STAP cells? Do people belief in them or not? Our STAP poll #8 polling results on STAP are in with more than 1000 respondents. The poll question was “Do you believe in STAP cells?” I will start STAP poll #9 soon. The poll #8 results remain about the same but there has been a slight shift toward more people indicating they are at least leaning positive. Again, recall that this polling is not scientific.