September 24, 2020

The Niche

Knoepfler lab stem cell blog

cancer stem cells

2 min read

Dr. John Dick gave a great talk yesterday on cancer stem cells here at ISSCR 2016. Below I summarize his talk and as always with these meeting blogs, the post is not polished and is more of a stream of the speaker’s main points. He started out broadly with a nice introduction to this area of research. There’s a lot of controversy around cancer stem cells (CSC). How many tumors have CSCs? How different are cells within the same tumor? The normal hierarchical organization of …Read More

4 min read

Many of this blog’s readers ask about my own lab’s research: what is the focus of the work in the Knoepfler Lab? You can go check out our lab website, but I thought it might be time again to blog about what we are all about as a lab and what we have been up to most recently. I am fortunate to have an exceptional team of researchers in my lab. Our mission is to advance knowledge toward two main goals: (1) the development …Read More

3 min read

By Aaron Goldman Much like the winter weather we’ve been enduring on the east coast, cancer research is advancing at a rapid clip! For decades, researchers have considered pools of “cancer stem cells” (CSC) as the subsets within a tumor which both initiate progression and underpin the failure of therapy. Over the past 5 years, however, a number of published studies have expanded this concept by putting a greater emphasis on the inherent plasticity of cancer cells allowing for reversibility in the cell hierarchy …Read More

3 min read

A new paper in Science by Bert Vogelstein suggests that a good part of cancer is attributable to bad luck. There are so many big questions about cancer. They resonate with me very strongly as a cancer researcher and a cancer survivor myself (more on my cancer story here). What really causes cancer? Why does it feel sometimes like we are struggling so much in the “War on Cancer”? What is the role of stem cells in cancer and are there “cancer stem cells“? …Read More