August 8, 2020

The Niche

Knoepfler lab stem cell blog

cardiac stem cells

1 min read

Can stem cells mend a broken heart via cardiac regenerative medicine? The idea of the use of stem cells and regenerative medicine strategies for heart disease has taken us on a roller coaster ride over the years. There are many controversial questions still such as whether the adult heart has meaningful populations of endogenous stem cells. Can administration of stem cells help a damaged heart? Where do things stand today? As Deepak Srivastava, cardiac stem cell expert, told in me for a past blog post …Read More

2 min read

Can hearts repair themselves via stem cell-like mechanisms? Sometimes what we scientists all know to be true turns out later on to be wrong and there are clear instances of this in the stem cell field. For example for decades the dogma was that the adult mammalian brain did not have stem cells, but now everyone knows that the adult brain does have stem cells. What we perceive as factual can change over time. Yamanaka disproved the entrenched notion that differentiated cells were permanently locked into …Read More

2 min read

Can hearts repair themselves via stem cell mechanisms including possibly their own stem cells? It’s a hot topic question at the center of a big debate in the stem cell field. My inclination at present is that the answer is most likely “no” at this point, but that could change and it’s important to keep an open mind. Sometimes what we scientists all know to be true turns out later on to be wrong and there are good examples of this in the stem …Read More