August 8, 2020

The Niche

Knoepfler lab stem cell blog

CRISPR baby

5 min read

Each year I make a list of stem cell predictions for the following year and I’ll release my predictions for 2019 soon, but first I’m grading how my 20 predictions for 2018 turned out. It seems I did better than usual predicting what would happen this year. I only got a couple partial credit or were hard to grade. The rest were right. Here are my 20 predictions verbatim that I made in late 2017 for what would happen in 2018. 1. Combo cell-gene …Read More

4 min read

Three national academy leaders have a new opinion piece in Science on what the community needs to do next regarding human germline editing now that we are most likely in the CRISPR babies era. Some of us have been wondering what the Academies and their empowered experts really think about this issue and what they are saying outside the public domain. Do some of them disagree with each other? There have been mixed messages. The new piece, entitled, Wake-up call from Hong Kong, gets a …Read More

4 min read

Could He Jiankui have faked part or all of his CRISPR babies story? If so, how? Why? Or to put it another way, almost everyone seems to be assuming the story is real, but should we be more skeptical? Should we flip things around and assume the story isn’t entirely kosher until proven otherwise? I once said that the CRISPR field feels like it moves in dog years (very fast!) Consistent with that warp speed, the last 2 weeks have felt more like months. In …Read More