August 9, 2020

The Niche

Knoepfler lab stem cell blog

CRISPR book

3 min read

A new paper was recently published on CRISPR of human embryos for genetic modification. I’ve got to read this publication more carefully, but here’s a quick initial take on this human CRISPR 2.0 study. The paper is Kang, et al. and is entitled “Introducing precise genetic modifications into human 3PN embryos by CRISPR/Cas-mediated genome editing”. This is only the second paper reporting genetic modification of human embryos. The first paper, also from China, created quite a stir last year and reported a lot of technical …Read More

2 min read

I like Easter eggs, science and writing, and Easter is less than a week away. I also think that games and puzzles as well as contests where there are prizes are fun. In this spirit I’ve hidden a scientific Easter egg inside of my new book, GMO Sapiens. If you are the first to find it and notify me, I will give you a $250 prize. We are talking about a scientific Easter egg. Wikipedia defines this sort of Easter egg this way: “An Easter egg is …Read More

3 min read

There’s a questionable notion floating around out there in the numerous discussions over heritable human genetic modification. This idea goes that if germline human gene editing goes awry for any number of reasons, scientists could simply reverse it by applying genetics again. The reversal notion does not fit with the reality of science as we know them today and could be harmful in giving false reassurance of the safety of genome modification. To put it another way, you can’t retract a designer baby or …Read More

2 min read

Who really invented CRISPR? If it was many people and labs, who did it first and who deserves the credit? When things like Nobel Prizes and Patents get decided on CRISPR-Cas9, who will be for lack of a better way of putting it, the winners and the losers? It’s not a trivial question and despite what some argue that CRISPR shouldn’t be patented at all, someone will get the decisive patent and the fight to see who prevails in the CRISPR patent battle is getting …Read More