October 1, 2020

The Niche

Knoepfler lab stem cell blog

CRISPR cancer

2 min read

Sometimes it seems like a bunch of stuff in one area, like with CRISPR this week, happens all of a sudden in science. A bunch of fairly high-profile gene editing pubs came out. They generated a lot of news reports. Other news in this arena popped up too, all within a few days. In vivo CRISPR editing with no detectable genome-wide off-target mutations over at Nature. In this context “no” is a really strong statement. Does the data back it up? See Figure 1a from …Read More

3 min read

Over the weekends I try to catch up on more diverse reading and sometimes come up with a list of stuff I want to get to during this time, but I also put together weekend reads usually on Fridays as a kind of TGIF on The Niche for the wider audience here. So here’s the weekend reads for this Friday the 13th including some wacky stuff at the end. Anti-Aging efforts got some play in the media including this LA Times piece. Here’s the …Read More

3 min read

Could potential associated cancer risks claw into CRISPR’s potential? The short answer from both previous and new data is that while CRISPR gene editing impacts the P53 pathway, which is involved in cancer along with having many other functions, this news is neither too surprising nor a fatal flaw, but some caution is warranted. CRISPR is many things including an exciting technology that my own lab uses a lot, but it isn’t and never will be perfect or somehow magical. When this week’s story …Read More